| 土元乳液对胃癌化疗药物增效作用的体外研究 |
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| 引用本文： | 郑昱,刘宝瑞,邹玺.土元乳液对胃癌化疗药物增效作用的体外研究[J].中国临床药理学与治疗学,2006,11(3):354-356. |
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| 作者姓名： | 郑昱 刘宝瑞 邹玺 |
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| 作者单位： | 南京大学医学院附属鼓楼医院肿瘤科,南京,210008,江苏 |
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| 摘 要： | 目的：比较土元乳液对胃癌化疗药物的体外增效作用。方法：采用MTT法体外药敏试验分别测定土元乳液与羟基喜树碱（HCPT）、氟尿嘧啶（5-Fu）、奥沙利铂（Oxa）、多西紫杉醇（泰素帝）体外对人胃癌细胞系BGC-823细胞株的药物敏感性，通过Weeb系数比较细胞生存率（fa），分析土元乳液对其体外增效作用，得出土元乳液最佳体外增效药物。结果：土元乳液对HCPT、Oxa的高中低3个剂量组体外药敏试验增效作用较好，增效作用明显高于5-Fu、泰素帝组（P〈0．05）。结论：土元乳液对HCPT、Oxa有更高的体外增效作用，从而有益于临床上合理配伍用药，更能有效提高临床上联合化疗对肿瘤的抑制率。
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| 关 键 词： | 土元乳液 增效作用 胃癌 化学治疗 |
| 文章编号： | 1009-2501(2006)03-0354-03 |
| 收稿时间： | 02 8 2006 12:00AM |
| 修稿时间： | 02 23 2006 12:00AM |
Comparative study of synergistic effect of eupolyphaga on chemotherapeutics of digestive canal cancer |
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| ZHENG Yu,LIU Bao-riu,ZOU Xi.Comparative study of synergistic effect of eupolyphaga on chemotherapeutics of digestive canal cancer[J].Chinese Journal of Clinical Pharmacology and Therapeutics,2006,11(3):354-356. |
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| Authors: | ZHENG Yu LIU Bao-riu ZOU Xi |
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| Institution: | Department of Oncoma, Gulou Hospital of Nanjing University, Nanjing 210008, Jiangsu, China |
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| Abstract: | AIM:To compare the synergistic effect of eupolyphaga on chemotherapeutics of digestive canal cancer.METHODS: Drug sensitivity of stomach cancer cell(BGC-823) was determined in vitro by MTT anti-tumor screening assay for eupolyphaga with HCPT,5-Fu,Oxa,docelaxel,by comparing cell inhibition,the synergistic effect of eupolyphaga was analysed to find the best synergistic drug.RESULTS: The synergistic effects of eupolyghaga were more significant in HCPT and Oxa than those of 5-Fu and docelaxel in vitro(P<(0.05)).CONCLUSION: Eupolyphaga has a higher sensitivity in clinical routine chemotherapeutic regimens for stomach neoplamas cells in vitro. |
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| Keywords: | eupolyphaga chemotherapeutic on stomach cancer synergistic effect anti-tumor |
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