低剂量干扰素-α在治疗ET中的应用

目的探讨低剂量的干扰素-α在治疗原发性血小板增多症（ET）中的疗效、副作用及对预后的影响。方法对我院1997年1月～2006年12月间诊断为ET经过干扰素-α治疗的患者进行回顾性分析。结果12例患者中男女各6例，就诊时中位年龄52岁（33—82岁）。经过干扰素-α治疗6个月，完全缓解（CR）4例，部分缓解（PR）5例，无效（NR）3例；治疗12个月CR6例，PR5例，NR1例。治疗有效者骨髓巨核细胞均减少，脾脏缩小，出血及血栓均明显控制。随访1．5-2年，CR6例，PR5例，复发1例。治疗过程中的副作用主要表现为流感样症状，但均能耐受。结论低剂量干扰素-α治疗ET能取得很好的疗效及较好的耐受性，但需长期治疗。

Clinical application of low-dose interferon alpha treatment in essential thrombocythemia

Objective To explore the effect of low dose of interferon alpha on efficacy, side-effect and prognosis of essential thrombecythemia （ET） patients. Methods ET patients diagnosed in our hospital from January 1997 to December 2006 were retrospectively analyzed. Results Twelve patients include 6 males and 6 females, with a median age of 52 years ranging from 33 to 82 years.After low-dose interferon alpha treatment for 6 months,patients achieved complete remission（CR, n=4）,partial remission （PR,n=5）,and non response （NR,n=3）,respeetively.Mter 12 months,there were CR in 6 eases,PR in 5 cases,NR in 1 ease,respectively. The number of megakaryocyte in bone marrow reduced, spleens withdrew, hemorrhage and thrombosis were significantly controlled in those effectively treated.Twelve patients were followed-up over 1.5 to 2 years, there were CR in 6 cases,PR in 5 cases,relapse in 1 case,respectively. The main side effect was flu-like syndrome and patients could continue to receive interferon therapy. Conclusion The patients were well responsive and tolerant to interferon-α,hut the patients must be treated for a longer period.