睡眠呼吸暂停综合症对C-反应蛋白、左房及房性早搏的影响(英文)

目的评估血清C-反应蛋白(CRP)的浓度、左房大小和房性早搏与睡眠呼吸暂停综合症(OSAS)的关系。方法经多导睡眠呼吸监测诊断为OSAS的277名患者行24 h动态心电图和动态血压检查。将发现有房性早搏的137名患者根据呼吸暂停低通气指数(AHI)分成3组,即轻度组(5≤AHI<15),中度组(15≤AHI<30)和重度组(AHI≥30)。比较3组患者的血清CRP浓度、左房直径,分析二者与OSAS严重程度之间的关系。结果 OSAS患者中,房性早搏的发生率较高,为49.4%(134/277)。轻、中、重度OSAS患者的CRP值分别为(2.98±1.82)mg/L,(3.03±1.94)mg/L,(5.01±4.68)mg/L,左房直径分别为(33.7±3.8)mm,(37.9±5.5)mm,(40.1±7.9)mm。血清CRP水平和左房直径与OSAS的严重程度成正相关(r=0.304,P=0.034;r=0.411,P=0.003)。在排除性别、年龄和体质量指数的影响下,CRP和左房直径也呈正相关(r=0.594,P=0.0005)。结论 OSAS患者房性早搏的发病率较高。在这些患有房性早搏的OSAS患者中,CRP水平和左房直径的大小与OSAS的严重程度成正相关的关系,提示炎症激活介导的左房重构和电重构可能在OSAS患者房性早搏的发生中起重要作用。

Effect of obstructive sleep apnea syndrome on serum C-reactive protein level,left atrial size and premature atrial contraction

Objective To assess the changes of serum C-reactive protein(CRP) level,left atrial size and atrial premature contraction(PAC) in patients with obstructive sleep apnea syndrome(OSAS).Methods This study involved 277 patients with OSAS diagnosed after an overnight polysomnography,who underwent a 24-h Holter electrocardiography and ambulatory blood pressure monitoring for detection of PAC.According to the apnea-hypopnea index(AHI),137 patients with PAC identified from these patients were classified into 3 group...