冠心病患者血清VEGF水平的研究

目的 :观测冠心病患者血清血管内皮生长因子 （VEGF）的水平。方法 :行选择性冠脉造影 （SCA）的患者 6 0例 ,分为 4组 ,其中 SCA正常者 10例作为对照组 ,急性心肌梗死 （AMI）组 2 0例 ,陈旧性心肌梗死 （OMI）组 10例 ,心绞痛 （AP）组 2 0例 ,使用 EL ISA方法分别检测其血清 VEGF的水平。结果 :AMI患者血清 VEGF水平显著高于其它各组 （P<0 .0 1） ,且其 VEGF的水平与心肌梗死部位、病变血管及血管病变程度无关 ,AP、OMI组血清 VEGF略高于对照组 ,但无统计学差异 （P>0 .0 5 ）。结论 :AMI患者血清 VEGF水平升高。

Study of the serum VEGF levels in patients with coronary heart disease

AIM:To study the serum vascular endothelial growth factor (VEGF) levels in patients with coronary heart disease. METHODS:60 patients who had undergone selective coronary angiography were divided into four groups. 10 patients with normal coronary artery served as the control group, and 20 acute myocardial infarction (AMI), 10 old myocardial infarction (OMI), 20 angina pectoris (AP) were the experimental subjects. The levels of serum VEGF were measured by ELISA. RESULTS:The serum VEGF levels in the AMI patients were higher than those in the AP and OMI patients and the control(P<0.01). There was no relationship betweenship serum VEGF levels and infarction location, infarct-related vessels, and extent of coronary artery disease. The serum VEGF levels in AP and OMI patients increased without statistical significance (P>0.05). CONCLUSION:The serum VEGF levels may be elevated during the healing process after AMI.