| 映山红总黄酮抗炎作用的实验研究 |
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| 引用本文： | 刘必全,胡勇,张建华,陈志武. 映山红总黄酮抗炎作用的实验研究[J]. 中国临床保健杂志, 2007, 10(2): 169-171 |
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| 作者姓名： | 刘必全 胡勇 张建华 陈志武 |
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| 作者单位： | 安徽医科大学第一附属医院骨二科,合肥,230022;安徽医科大学药理学教研室 |
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| 摘 要： | 目的研究映山红总黄酮(TFR)的抗炎作用及其可能的机制。方法通过二甲苯致小鼠耳肿胀和蛋清致大鼠足爪肿胀模型观察TFR的抗炎作用,并测定大鼠血清和足爪组织中一氧化氮(NO)、丙二醛(MDA)、前列腺素E2(PGE2)的含量和一氧化氮合酶(NOS)活性。结果50、100 mg/kg的TFR能明显抑制二甲苯致小鼠耳片肿胀;25、50、100 mg/kg的TFR可显著抑制蛋清致大鼠足爪的肿胀;在蛋清诱导大鼠足爪肿胀模型中,TFR使血清和脚爪组织屮MDA含量减少,同时脚爪组织中NOS活性、NO和PGE2含量也有显著的下降。结论TFR有一定的抗炎作用,其作用可能与抑制PGE2和NO合成及抗脂质过氧化有关。
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| 关 键 词： | 生物黄酮类 一氧化氮 丙二醛 地诺前列酮 模型 动物 |
| 文章编号： | 24079649 |
| 修稿时间： | 2006-10-20 |
The anti-inflammatory effect of total flavones of rhododendra and its mechanisms |
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| LIU Biquan,HU Yong,ZHANG Jianhua,CHEN Zhiwu. The anti-inflammatory effect of total flavones of rhododendra and its mechanisms[J]. Chinese Journal of Clinical Healthcare, 2007, 10(2): 169-171 |
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| Authors: | LIU Biquan HU Yong ZHANG Jianhua CHEN Zhiwu |
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| Affiliation: | 1. Second Department of Orthopedic, The First Affiliated Hospital of Anhui Medical University, Hef ei 230022, China ;2. Anhui Medical University |
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| Abstract: | Objective To study the anti-inflammatory effect of total flavones of rhododendra(TFR) and its mechanisms.Methods The inflammatory models were made by dimethylbenzene-induced edema of mice ear and egg white-induced swelling of rat paw,respectively.The NOS activity and contents of PGE2,MDA and NO in rat serum and paw tissue were measured.Results 50,100 mg/kg TFR significantly inhibited the ear edema induced by dimethylbenzene;25,50,100 mg/kg TFR markedly inhibited egg white-induced the swelling of rat paw.On the model of egg white-induced swelling of rat paw,TFR in the range of 25 ～ 100 mg/kg significantly decreased MDA contents of rat serum and paw tissue,50,100 mg/kg TFR markedly inhibited NOS activity and contents of PGE2 and NO in rat paw tissue.Conclusion TFR has an anti-inflammatory effect,which may be related to inhibiting the production of PGE2,NO and free radical. |
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| Keywords: | Bioflavonoids Nitric oxide Malondialdehyde Dinoprostone Models animal |
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