代谢综合征与颈动脉粥样硬化关系的研究

目的探讨代谢综合征(MS)与颈动脉粥样硬化的关系。方法110例研究对象根据中华医学会糖尿病学分会(CDS)关于MS的诊断建议分为MS组52例(具有3~4项组分者)、MS亚组28例(具有1~2项组分者)以及对照组30例(具有0项组分者)。应用多普勒超声检测颈总动脉(CCA)与颈内动脉(ICA)内膜中层厚度(IMT)并观察颈动脉系统有无斑块存在。比较三组间颈动脉粥样硬化的程度。结果CCA-IMT、ICA-IMT在MS组和MS亚组显著高于对照组,P均<0.01;CCA-IMT与体重指数、腰臀比、收缩压、舒张压以及胰岛素抵抗指数(HOMA-IR)呈显著正相关(r分别为0.193、0.209、0.478、0.362及0.471,P分别<0.05,0.05,0.01,0.01,0.01)。随着MS代谢组分的增多,颈动脉IMT逐渐增厚,颈动脉系统斑块发生率明显升高。结论颈动脉粥样硬化程度与MS聚集的组分密切相关。颈动脉超声检查可早期发现动脉粥样硬化。

Association between metabolic syndrome and carotid atherosclerosis

Objective To investigate the association and significance between metabolic syndrome (MS) and carotid atherosclerosis. Methods Accoding to the definition of MS by CDS in 2004,110 subjects were enrolled and divided into three groups,including MS group with between 3 to 4 components (n=52),MS subgroup with between 1 to 2 components (n=28),and controll group (n=30). Carotid intima-media thickness (IMT) was detected and the atherosclerotic plagues were measured. Results Both the IMT and the occurrence of atherosclerotic plagues were higher in MS group and in MS subgroup as compared with controll group. CCA-IMT was positively correlate with body mass index,waist-hip ratio,systolic blood pressure,diastolic blood pressure and HOMA-IR significantly. The prevalence of carotid atherosclerosis continually increased with the amount of components of MS. Conclusion The MS accelerated the occurrence and progress of carotid atherosclerosis. Clustering of multiple components may cause more severe carotid atherosclerosis in MS. Carotid ultrasound may help diagnosis atherosclerosis much earlier.