GM1对HIE患儿血清NSE水平的影响

目的探讨GM1对HIE患儿血清NSE（neumnspecmceno1ase）水平的影响。方法62例新生儿缺氧缺血性脑病患儿按照人院先后顺序随机分为GM1组32例及对照组30例。两组给予常规治疗，GM1组在常规治疗的基础上给予神经节苷脂（GM1）20mg静滴。1次／d，7—14d为1疗程，于治疗前后评估两组的疗效及治疗后第14天、治疗后第28天NABA的变化．以及治疗后两组NSE水平变化，不同严重程度HIE患儿NSE的变化。结果GMI组及对照组治疗后第14天。及治疗后第28天的NABA评分均分别较治疗前明显升高，且GM1组的NABA评分较对照组升高更明显，差异有统计学意义（P〈0．05）。GM1组及对照组治疗后第28天NABA评分均明显高于治疗后第14天，GM1组也明显高于对照组，差异有统计学意义（P〈0．05）。GM1治疗后有效率为93．75％，对照组为73．33％；GM1的有效率明显高于对照组。组间比较有统计学意义（P〈O．05），62例HIE患儿随着病情程度的加重，血清NSE水平也明显升高。均明显高于健康对照组新生儿NSE水平，且重度HIE患儿的血清NSE水平分别明显高于轻度及中度HIE患儿．而中度HIE患儿的血清NSE水平明显高于轻度HIE患儿，却明显低于重度HIE患儿，组间比较有统计学意义（P〈0．05）。GM1组及对照组治疗后第14天检测NSE水平与治疗前比较均明显降低，且GM1组明显低于对照组。结论GM1对新生儿缺氧缺血性脑病有效且安全，能明显降低NSE水平，副作用少，值得临床推广。

The impact of GM1 on serum NSE level in hypoxic-ischemic encephalopathy infants

Objective To explore the ganglioside(GM1) on neonatal hypoxic-ischemic enceph-alopathy(HIE) in children and its effect on serum neuronspecificenolase(NSE) levels.Methods From January 2008 January 2011 in our hospital,62 cases neonatal hypoxic-ischemic enceph-alopathy were randomly divided into GM1 group(32 patients) and control group(30 patients).Two groups received conventional therapy,GM1 group in the conventional treatment given on the basis of ganglioside(GM1) 20 mg intravenously,1/d,7-14 d as a course evaluation before and after treatment and the efficacy of the two groups after treatment 14 days,after treatment 28 days,changes in NABA and NSE levels in both groups after treatment,children with different severity of HIE NSE changes.Results GM1 treatment group and control group after 14 days and 28 days after treatment,respectively,both NABA score were significantly higher than that before treatment,and the GM1 group NABA score increased more were significantly than the control group,there was significant difference(P < 0.05).And GM1 treatment group and control group 28 days after NABA scores after treatment were significantly higher than the 14th day,GM1 group was also significantly higher,there was significantly different(P < 0.05).GM1 treatment after the effective rate was 93.75% in the control group after treatment,the effective rate was 73.33% in the control group;GM1 had significantly higher efficiency between the two groups were significantly different(P < 0.05),62 cases of HIE severity in children with the increase,significantly higher serum NSE levels were significantly higher than the healthy control group of neonatal NSE levels,and children with severe HIE serum NSE levels were significantly higher than children with mild and moderate HIE,while patients with moderate HIE children with serum NSE levels were significantly higher than children with mild HIE serum NSE level was significantly lower than in children with severe HIE serum NSE levels between the two groups were significantly different(P < 0.05).GM1 treatment group and control group 14 days after detection of NSE levels before treatment were significantly lower,and the GM1 group was significantly lower than the control group between the two groups were significantly different(P < 0.05).Conclusion GM1 on neonatal hypoxic-ischemic encephalopathy is effective and safe,can significantly reduce the NSE levels,less side effects.