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| HBIG联合国产、进口重组乙型肝炎疫苗阻断乙型肝炎母婴传播的效果观察 | |
| 引用本文： | 李文戈,高奇峰,卢潮,董妃兴,林社润,刘洪波.HBIG联合国产、进口重组乙型肝炎疫苗阻断乙型肝炎母婴传播的效果观察[J].中国现代医生,2012,50(9):41-42. |
| 作者姓名： | 李文戈 高奇峰 卢潮 董妃兴 林社润 刘洪波 |
| 作者单位： | 1. 广东省中山市人民医院东区防保所,广东中山,528403 2. 广东省中山市南区防保所,广东中山,528455 3. 广东省中山市阜沙防保所,广东中山,528434 4. 广东省中山市疾病预防控制中心,广东中山,528403 |
| 基金项目： | 2009年广东省中山市卫生局医学科研立项课题 |
| 摘 要： | 目的了解乙肝免疫球旦白（HBIG）分别联合相同剂量国产、进口重组（酵母）乙肝疫苗阻断乙肝病毒（HBV）母婴传播的效果。方法用HBIG分别联合国产、进口乙肝疫苗10μg／0．5mL免疫乙肝病毒表面抗原（HBsAg）、乙肝病毒膜抗原（HBeAg）双阳性或只有HBsAg阳性母亲的新生儿共130例，采用0、1、6个月接种程序，测定乙肝病毒表面抗体（抗-HBS）滴度及HBsAg。结果国产组新生儿HBsAg阳性率为1．49％，保护率为98．14％；进口组新生儿HBsAg阳性率4．76％，保护率为94．05％。两组间比较差异无统计学意义（P〉0．05）。结论HBIG联合国产、进口10μg乙型肝炎重组（酵母）疫苗阻断乙肝母婴传播的效果同样良好。 |
| 关 键 词： | 重组乙型肝炎疫苗（酵母） 免疫效果 |
Research on perinatal transmission of hepatitis B virus using identical doses yeast-derived hepatitis B vaccine |
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| Authors: | LI Wenge GAO Qifeng LU Chao DONG Feixing LIN Sherun LIU Hongbo |
| Institution: | 1.East District Preventive and Health Care Centre,People’s Hospital of Zhongshan City in Guangdong Province,Zhongshan 528403,China;2.South District Preventive and Health Care Centre of Zhongshan City in Guangdong Province,Zhongshan 528455,China;3.Fusha Preventive and Health Care Centre of Zhongshan City in Guangdong Province,Zhongshan 528434,China;4.Centre for Disease Control and Prevention of Zhongshan City in Guangdong Province,Zhongshan 528403,China |
| Abstract: | Objective To study the efficacy of HBIG unite identical doses yeast-derived hepatitis B vaccine(YDV) to interrupt perinatal transimission.Methods Neonates born to HBsAg or HBsAg,HBeAg carrier mother were vaccined the same doses(10μg) hepatitis B vaccine(YDV) in two groups(internal,import) by 0,1,6 month schedule.The immunization effect was used by serum epidemiological survey.Results Vaccined newborns HBsAg positive rate of internal group was 1.49%,the protective rate was 98.14%.Those of import group was 4.76%,94.05%.There were no statistical differences between the two groups(P >0.05).Conclusion HBIG unite internal or import 10μg doses of YDV revealed the same high efficacy of interrupting perinatal transmission. |
| Keywords: | Yeast-derived hepatitis B vaccine Immunogenicity |
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