Study of Etiologic Relationship of Arterial Atherosclerosis to Corporal Veno-Occlusive Dysfunction in the Rabbit |
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Authors: | Kazem M. Azadzoi Mike B. Siroky Irwin Goldstein |
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Affiliation: | Department of Urology, Boston Veterans Affairs Medical Center and the Department of Urology, Boston University Medical Center, Boston, Massachusetts. |
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Abstract: | PurposeThe aim of this study was to explore the possible etiologic relationship of hypercholesterolemia and atherosclerosis to corporal veno-occlusive dysfunction.Materials and MethodsIn the New Zealand White rabbit, the competence of the corporal veno-occlusive mechanism was examined at various intervals after exposure to control diet, high cholesterol diet, or aortoiliac atherosclerosis.ResultsInitially, all animals showed normal erectile function and corporal veno-occlusion. After 8 weeks and 16 weeks, the control animals preserved normal erection and corporal veno-occlusion, while most of the hypercholesterolemic and atherosclerotic animals developed corporal veno-occlusive dysfunction. The incidence of corporal veno-occlusive dysfunction in the hypercholesterolemia and atherosclerotic animals increased with time.ConclusionsThis study suggests that a close relationship exists between prolonged atherosclerotic occlusion of major penile arteries and the development of corporal veno-occlusive dysfunction. Ischemia-induced corporal veno-occlusive dysfunction may be the result of alterations in corporal smooth muscle relaxation or changes in the structure and fibroelastic properties of erectile tissue. |
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