血小板活化与炎症反应在高血压患者中的改变及其相关性研究

目的 探讨高血压患者血小板活化与炎症反应的改变及其相关性.方法 选择61例原发性高血压患者(高血压组)和64例阵发性室上性心动过速患者(对照组),测定其血清超敏C-反应蛋白(hs-CRP)及平均血小板体积.结果 高血压组患者血清hs-CRP浓度[(3.51±1.95)mg/L]明显高于对照组[(1.15±0.77)mg/L],差异有统计学意义(P＜0.05),平均血小板体积大于对照组[分别为(11.19±2.18)fl与(9.20±2.31)fl],差异有统计学意义(P＜0.05),两者之间呈线性相关(r=0.452,P=0.003).结论 高血压患者存在炎症反应及血小板活化,作为炎症反应及血小板活化的两个观察指标,两者相互作用具有相关性,与高血压的发生发展有密切关系.

Abstract：

Objective To investigate the changes and correlation between platelet activation and inflammatory response in patients with essential hypertension(EH). Methods Sixty-one patients with essential hypertension and sixty-four patients with paroxysmal supraventricular tachycardia as control group were enrolled in the study. The levels of high sensitivity C reactive protein ( hs-CRP ) and mean platelet volume ( MPV ) were measured and compared between the control group and the essential hypertension group. Results Compared with the control group,the levels of hs-CRP and MPV in the EH group were significantly higher( [3.51 ± 1.95]mg/L vs [ 1.15 ± 0. 77 ] mg/L, P ＜ 0. 05 ). The MPV in the EH group was significantly higher than that in the control group ( [ 11.29 ± 2. 18 ] flvs [ 9. 20 ± 2. 31 ] fl, P ＜ 0. 05 ). The level of hs-CRP positively correlated to the level of M PV (r = 0. 452, P = 0. 003 ). Conlusions There were inflammatory response and platelet activation in patients with EH and the serum levels of hs-CRP and MPV is correlated with the development of essential hypertension.

Changes and correlation between platelet activation and inflammatory response in patients with essential hypertension

Objective To investigate the changes and correlation between platelet activation and inflammatory response in patients with essential hypertension(EH). Methods Sixty-one patients with essential hypertension and sixty-four patients with paroxysmal supraventricular tachycardia as control group were enrolled in the study. The levels of high sensitivity C reactive protein ( hs-CRP ) and mean platelet volume ( MPV ) were measured and compared between the control group and the essential hypertension group. Results Compared with the control group,the levels of hs-CRP and MPV in the EH group were significantly higher( [3.51 ± 1.95]mg/L vs [ 1.15 ± 0. 77 ] mg/L, P ＜ 0. 05 ). The MPV in the EH group was significantly higher than that in the control group ( [ 11.29 ± 2. 18 ] flvs [ 9. 20 ± 2. 31 ] fl, P ＜ 0. 05 ). The level of hs-CRP positively correlated to the level of M PV (r = 0. 452, P = 0. 003 ). Conlusions There were inflammatory response and platelet activation in patients with EH and the serum levels of hs-CRP and MPV is correlated with the development of essential hypertension.