内镜下氟尿嘧啶缓释化疗粒子植入治疗晚期消化道肿瘤的短期疗效观察

目的 探讨内镜下氟尿嘧啶(5-FU)缓释化疗粒子植入治疗晚期胃、肠道肿瘤的可行性、安全性及短期疗效.方法 内镜直视下对胃、肠道肿瘤结节及浸润处行多点或密集型植入粒子(每粒含5-FU 1.67 mg),45～60粒,平均注射5-FU缓释粒子100 mg.结果 13例患者施行粒子植入治疗后,临床症状解除显效4例,有效7例,无效2例,总有效率84.62%,1～2个月后复查内镜可见病灶局部不同程度的表现出病变局限、平坦、腔径增宽.所有患者均未发生出血、穿孔等并发症,肝、肾功能及血常规检查未见异常.结论 内镜直视下瘤体内局部植入5-FU缓释粒子治疗中、晚期胃肠道肿瘤,能有效的改善患者症状,限制肿瘤生长,无明显骨髓、肝肾功能损害等不良反应,临床效果较好.

Abstract：

Objective To investigate the feasibility, safety and short-term efficacy of endoscopic implantation of 5-FU Slow-release Particles for advanced gastroenteric tumor. Methods During the endoscopy procedure,slow-releasing 5-FU agents were implanted densely into the tumors and infiltrated area. Forty-five to sixty pieces of agents ( each piece equivalent to 1.67 mg 5-FU)were injected, which containing an average dose of 100 mg 5-FU. Results A total of 13 advanced gastric cancer patients were enrolled into this study. Significant effects were observed in 3 patients and good effects in 8 patients, but 2 cases with no effects. The total effective rate was 84.62%. The endoscopy examination showed that the size of tumors reduced in various degree at 1 - 2months after the implantation. No hemorrhage or perforation was observed. Parameters of hepatorenal function and routine blood test were stable after implantation. Conclusion Endoscopic implantation of 5-FU Slow-release Particles can relieve the symptoms of patients and limit tumor growth in advanced gastroenteric tumor with no marrow and hepatorenal functional impair.

Endoscopic implantation of 5-FU slow-release particles for advanced gastroenteric tumor

Objective To investigate the feasibility, safety and short-term efficacy of endoscopic implantation of 5-FU Slow-release Particles for advanced gastroenteric tumor. Methods During the endoscopy procedure,slow-releasing 5-FU agents were implanted densely into the tumors and infiltrated area. Forty-five to sixty pieces of agents ( each piece equivalent to 1.67 mg 5-FU)were injected, which containing an average dose of 100 mg 5-FU. Results A total of 13 advanced gastric cancer patients were enrolled into this study. Significant effects were observed in 3 patients and good effects in 8 patients, but 2 cases with no effects. The total effective rate was 84.62%. The endoscopy examination showed that the size of tumors reduced in various degree at 1 - 2months after the implantation. No hemorrhage or perforation was observed. Parameters of hepatorenal function and routine blood test were stable after implantation. Conclusion Endoscopic implantation of 5-FU Slow-release Particles can relieve the symptoms of patients and limit tumor growth in advanced gastroenteric tumor with no marrow and hepatorenal functional impair.