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| GXXXG结构对老年性痴呆相关蛋白功能调节研究进展 | |
| 引用本文： | 吴彦霖,辛晓洁,辛现良,耿美玉.GXXXG结构对老年性痴呆相关蛋白功能调节研究进展[J].中国药理学通报,2011,27(1):1-4. |
| 作者姓名： | 吴彦霖 辛晓洁 辛现良 耿美玉 |
| 作者单位： | 1. 中国海洋大学医药学院分子药理室,山东,青岛,266003;海洋药物教育部重点实验室,山东,青岛,266003 2. 潍坊医学院,山东,潍坊,261053 3. 中国科学院上海药物研究所国家新药研究重点实验室肿瘤药理组,上海,201023 4. 中国海洋大学医药学院分子药理室,山东,青岛,266003;中国科学院上海药物研究所国家新药研究重点实验室肿瘤药理组,上海,201023;海洋药物教育部重点实验室,山东,青岛,266003 |
| 基金项目： | 国家杰出青年科学基金资助项目 |
| 摘 要： | Aβ是阿尔采末病(Alzheimer's disease,AD)最重要的致病因子之一,也是当前国际抗AD药物研究的热点。Aβ生成抑制剂是抗AD药物研究的重要方向之一。研究发现,与Aβ生成相关的蛋白,包括淀粉样前体蛋白APP,γ分泌酶复合物组成蛋白PS-1和APH-1,跨膜区均有一特殊蛋白序列GXXXG的结构修饰,GXXXG修饰通过自身形成二级结构,从而影响下游Aβ的生成和聚集。该文通过阐述GXXXG结构对AD相关蛋白功能的调节,为以GXXXG结构为靶向,进而影响Aβ生成的抗AD药物研究提供思路拓展。 |
| 关 键 词： | GXXXG结构 Aβ生成 Aβ聚集 老年性痴呆 淀粉样前体蛋白 γ分泌酶 |
Research progress about the regulation of GXXXG structures in the Alzheimer-related protein |
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| WU Yan-lin,XIN Xiao-jie,XIN Xian-liang,GENG Mei-yu.Research progress about the regulation of GXXXG structures in the Alzheimer-related protein[J].Chinese Pharmacological Bulletin,2011,27(1):1-4. | |
| Authors: | WU Yan-lin XIN Xiao-jie XIN Xian-liang GENG Mei-yu |
| Institution: | WU Yan-lin1,4,XIN Xiao-jie3,XIN Xian-liang2,GENG Mei-yu1,2,4(1.School of Medicine and Pharmacy,Ocean University of China,Qingdao Shandong 266003,China,2.Division of Anti-tumor Pharmacology,State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,3.Weifang Medical University,Weifang Shandong 261053,4.Key Laboratory of Marine Drugs,Ministry of Education,China) |
| Abstract: | As a key factor of Alzheimer's disease(AD),β-amyloid(Aβ)has emerged as an attractive drug target.Aβ species produced inhibitor is one of the most important aspects in anti-AD drug research and developement.Recent advances showed that some Aβ-related proteins,including β-amyloid precursor protein(APP),γ-secretase complex PS-1 and APH-1,have a special structure in transmembrane sequence(TMS),an amino-acid motif GXXXG,which has a regulatory impact on Aβ species production and aggregation.This paper describes the regulation of GXXXG structure to the function of AD-related proteins,which may hold the promise for the development of anti-AD drugs. |
| Keywords: | GXXXG structure Aβ production Aβ aggregation Alzheimer's disease APP γ-secretase complex |
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