| 雷公藤多甙对类风湿关节炎患者滑膜细胞凋亡的影响 |
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| 引用本文： | 周光伟,沈权,金若珏,王晓东,曾云祥,叶澄宇. 雷公藤多甙对类风湿关节炎患者滑膜细胞凋亡的影响[J]. 浙江临床医学, 2007, 9(8): 1034-1035 |
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| 作者姓名： | 周光伟 沈权 金若珏 王晓东 曾云祥 叶澄宇 |
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| 作者单位： | 1. 325000,浙江省温州市第八人民医院
2. 325000,温州医学院附属第一医院 |
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| 基金项目： | 温州市鹿城区科学技术局资助项目（S040210） |
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| 摘 要： | 目的观察雷公藤多甙（Tripterygium Glycosides,TG）对类风湿关节炎（rheumatoidarthritis,RA）患者滑膜细胞凋亡的影响,以揭示TG治疗RA可能的作用机制。方法体外培养RA患者滑膜细胞,加入不同浓度的TG,24h光镜观察其凋亡的形态学特征,并用流式细胞仪及TUNEL法检测滑膜细胞的凋亡。结果TG组凋亡细胞百分率（55±11.2）%,显著高于骨折（NC）组（P〈0.01）。结论TG可诱导滑膜细胞凋亡,这可能是其治疗RA的作用机制之一。
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| 关 键 词： | 类风湿关节炎 滑膜 雷公藤多甙 凋亡 |
Effects of tripterygium glycosides on synoviocyte''''s apoptosis of rheumatoid arthritis |
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| Zhou GuangWei,et al. Effects of tripterygium glycosides on synoviocyte''''s apoptosis of rheumatoid arthritis[J]. Zhejiang Clinical Medical Journal, 2007, 9(8): 1034-1035 |
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| Authors: | Zhou GuangWei et al |
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| Abstract: | Objective To observe the effects of tripteryglum glycosides（TG） on synoviocyte＇ s apoptosis of rheumatoid arthritis（RA） , in order to explore the possible mechanism of TG in treating RA . Methods Synoviocyte from RA patients were cultured in vivo , different concentrations of TG were added , the morphological charactors of synoviocyte＇s apaptosis was observed under light microscope 24 hours later, flow cytometry and TUNEL were used to detect the apoptosis of synoviocyte , Results The apoptosic cells was 55 % ~ 11.2% in TG group , which was significantly higher than that in bone fracture group（ P 〈 0.01 ）. Conclusios TG could induce the apaptosis of synoviocyte which may be one of its mechanism for treating RA. |
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| Keywords: | Rheumatoid arthritis Synovium Tripterygium glycosides Apoptosis |
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