Gustatory cortex in the rat. I. Physiological properties and cytoarchitecture |
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| Authors: | Eva Kosar Harvey J Grill Ralph Norgren |
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| Institution: | 1. Monell Chemical Senses Center, Philadelphia, PA 19104, U.S.A.;2. University of Pennsylvania, Philadelphia, PA 19104, U.S.A.;3. College of Medicine, Pennsylvania State University, Hershey, PA 17033 U.S.A.;1. INMED, Aix-Marseille University, INSERM U1249, Marseille 13273 CEDEX 09, France;2. LNC – Fédération de recherche 3C, Aix-Marseille University, CNRS UMR7291, Marseille 13331 CEDEX 03, France;1. Department of Bioengineering, University of Utah, Salt Lake City, UT;2. Division of Urology, Department of Surgery, School of Medicine, University of Utah, Salt Lake City, UT;1. Tsinghua University School of Medicine Beijing 100084, China;2. GlaxoSmithKline, R&D China, Shanghai 201203, China;3. Brain Mapping Unit, Department of Psychiatry, University of Cambridge, UK;4. School of Psychology and Psychiatry, Monash University, Melbourne, Australia;5. New Medicines, UCB Pharma, Brussels, Belgium;6. Head Clinical Pharmacology & Pharmacovigilance at University Hospital Marseille;1. Hannover Medical School, Department of Psychiatry, Social Psychiatry and Psychotherapy, Carl-Neuberg-Str. 1, 30625 Hannover, Germany;2. Paracelsus Medical University Nuremberg, Departement of Psychiatry and Psychotherapy, Prof.-Ernst-Nathan-Str. 1, 90419 Nuremberg, Germany |
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| Abstract: | The precise cytoarchitectural localization of taste-elicited cortical responses in the rat was studied using a combination of anatomical and physiological techniques. Multi-unit responses to tongue tactile, thermal and gustatory stimuli were recorded along 97 electrode penetrations positioned parallel to the lateral convexity of the brain and marking lesions were placed at the sites of transitions in these functional properties. Lesions made at sites that received different sensory inputs were consistently located within different cytoarchitectural subdivisions. In this manner, taste cortex in the rat was localized to the agranular insular cytoarchitectural region, in contrast to its traditional assignation to granular insular cortex. Instead, tongue temperature was found to be represented in the cortical area previously termed gustatory, i.e., in ventral granular cortex where layer IV attenuates. |
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| Keywords: | taste gustatory cortex cytoarchitecture rat agranular insular cortex |
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