| 迷走神经刺激对大鼠癫痫抑制的作用 |
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| 引用本文： | 杨红军,胡三觉.迷走神经刺激对大鼠癫痫抑制的作用[J].南方医科大学学报,2002,22(8):716-718，723. |
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| 作者姓名： | 杨红军 胡三觉 |
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| 作者单位： | 1. 广州军区广州总医院神经内科,广东,广州,510010
2. 第四军医大学神经科学研究所,陕西西安710033 |
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| 基金项目： | 国家自然科学基金(39970242) |
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| 摘 要： | 目的探索迷走神经刺激对癫痫的抑制作用。方法在青霉素诱发的大鼠癫痫模型上,记录大鼠癫痫活动时肌电、脑电以及单个神经元的电活动。电刺激迷走神经,以观察迷走神经刺激对大鼠癫痫的抑制作用。结果在动物行为、肌电和脑电、单个神经元等不同水平观察到迷走神经刺激对大鼠癫痫活动的抑制作用。在5~20 Hz范围内,随迷走神经刺激频率的增高,迷走神经刺激对大鼠癫痫的抑制程度逐渐增大。结论迷走神经刺激可以抑制大鼠癫痫活动,其抑制作用与刺激参数密切相关。
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| 关 键 词： | 癫痫 迷走神经 电刺激 |
| 文章编号： | 1000-2588(2002)08-0716-03 |
| 修稿时间： | 2002年4月11日 |
Seizure inhibition by vagal nerve stimulation in rats |
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| YANG Hong-jun ,HU San-jue.Seizure inhibition by vagal nerve stimulation in rats[J].Journal of Southern Medical University,2002,22(8):716-718，723. |
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| Authors: | YANG Hong-jun HU San-jue |
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| Institution: | YANG Hong-jun 1,HU San-jue 2 1 Department of Neurology,Guangzhou General Hospital of Guangzhou Command,Guangzhou 510010 China, 2 Institute of Neuroscience,Fourth Military Medical University,Xi'an 710033,China |
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| Abstract: | Objective To study the effect of vagal nerve stimulation in seizure inhibition in rats. Methods In rat epileptic models induced by penicillin, electromyogram (EMG), electroencephalogram (EEG) and extracellular electric activity of the cortex were recorded to study the inhibiting effect of vagal nerve stimulation on epilepsy. Results Inhibiting effect of vagal nerve stimulation on epilepsy was observed from the changes in behavior, EMG, EEG and extracellular electric activity of the rats, and this inhibiting effect was enhanced as the frequency for stimulation increased from 5 Hz to 20 Hz. Conclusion Vagal nerve stimulation can inhibit the epileptic activity in rats, the effect of which depends on the stimulation coditions imposed on the rats. |
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| Keywords: | vagal nerve stimulation epilepsy electrical stimulation |
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