| 离子色谱法测定厄贝沙坦中氰化物 |
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| 引用本文： | 李美君,汪秀林,姚仙珍,王美花. 离子色谱法测定厄贝沙坦中氰化物[J]. 中南药学, 2013, 11(2): 132-134 |
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| 作者姓名： | 李美君 汪秀林 姚仙珍 王美花 |
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| 作者单位： | 李美君(浙江天宇药业股份有限公司,浙江台州,318020)；汪秀林(浙江天宇药业股份有限公司,浙江台州,318020)；姚仙珍(浙江天宇药业股份有限公司,浙江台州,318020)；王美花(浙江天宇药业股份有限公司,浙江台州,318020)； |
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| 摘 要： | 目的建立离子色谱法测定厄贝沙坦中氰化物的含量。方法采用IonPac AS7（250 mm×2 mm）离子交换色谱柱,淋洗液采用0.1 mol.L^-1氢氧化钠和0.2 mol.L^-1乙酸钠,流速为0.3 mL.min-1。结果氰根离子在0.008～0.12μg.mL^-1线性关系良好（r2=0.999 7）,检测限为0.002μg.mL^-1。在所建立的色谱条件下,氰根离子与各常见阴离子之间的分离度良好。结论该方法简单快速,专属性强,结果准确,可用作厄贝沙坦中氰化物的含量的检测。
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| 关 键 词： | 厄贝沙坦 氰化物 离子色谱 |
Determination of cyanide in irbesartan by ion chromatography |
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| LI Mei-jun,WANG Xiu-lin,YAO Xian-zhen,WANG Mei-hua. Determination of cyanide in irbesartan by ion chromatography[J]. Central South Pharmacy, 2013, 11(2): 132-134 |
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| Authors: | LI Mei-jun WANG Xiu-lin YAO Xian-zhen WANG Mei-hua |
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| Affiliation: | (Zhejiang Tianyu Pharmaceutical Co., Ltd., Taizhou Zhe- jiang 318020) |
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| Abstract: | Objective To establish an ion chromatography method to determine cyanide in irbesartan. Methods Ionpac AS7 （250 mm×2 mm） ion exchange column was used to separate anions. The eluent used was 0.1 mol.L^-1 NaOH and 0.2 mol.L^-1 sodium acetate with a flow rate of 0.3 mL .min ^- 1. Results Cyanide and other common anions were well isolated. The calibration graph of cyanide was linear within 0.008 -- 0.12 μg.mL^ -1 （r^2 = 0.999 7）. The detection limit of cyanide was 0.002 μg .mL^ -1. Conclusion The method is simple, rapid, accurate and suitable for the determination of cyanide in irbesartan. |
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| Keywords: | irbesartan cyanide ion chromatography |
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