纳络酮对家兔酒精中毒后外伤性脑水肿的治疗作用

目的 研究纳络酮(NAL)对家兔急性酒精中毒后外伤性脑水肿的治疗作用。方法 经胃管注入乙醇致家兔急性酒精中毒,自由落体打击法制作外伤性脑水肿模型,并在伤后30min静注NAL 2mg/kg,以后每隔60min重复注射一次。测定伤后4h脑组织超氧化物歧化酶(SOD)活性、脂质过氧化物(LPO)含量及脑组织含水量,并与对照组比较。结果 治疗组与对照组比较,SOD活性增加(P<0.01),LPO含量降低(P<0.01),脑组织含水量减少(P<0.05)。结论 NAL有抗自由基作用并可减轻兔急性酒精中毒后外伤性脑水肿。

Effect of Naloxone on Traumatic Cerebral Edema Following Alcohol Intoxication in Rabbits

Objective To study the effect of naloxone on cerebral edema after traumatic injury in alcohol-intoxicated rabbits . Methods The effect of naloxone on cerebral edema was observed in 30 rabbits which were ramdomly and equally divided into 3 groups(A, B,and C) . In group B and C, the animals, which had been artificially intoxicated by aloohol, were used for the extab-lishment of model of traumatic brain injury according to Feeney method. The animals in the group C were then treated with maloxone while the animals of the other two groups served as control. Results The beneficial effects of naloxone on cerebral edema of traumatic rabbits were obvious in comparing with these which were not treated with the drug. The SOD level significantly increased ( P <0.01) , while the LPO contents markedly decreased ( P<0.01) . The brain water content of cerebral tissues in the naloxone-treated group was also lower than that in both group A and B ( P < 0.05) . Conclusions The authors concluded that naloxone might exert certain and-free radical effect which was beneficial to relieve the degree of cerebral elema after brain injury.