| 药物从片状溶胀控制释放系统中释放的数学模型 |
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| 引用本文： | 李凌冰,陈胜蓝. 药物从片状溶胀控制释放系统中释放的数学模型[J]. 生物医学工程研究, 2001, 20(4): 5-10 |
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| 作者姓名： | 李凌冰 陈胜蓝 |
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| 作者单位： | 1. 山东大学西区药学院药剂教研室,济南,250012
2. 山东大学东区校医院内科,济南,250012 |
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| 摘 要： | 本文对药物从可溶胀高分子材料中释放的机理进行了研究.建立了药物从可溶胀高分子材料中释放的数学模型.同时考虑溶剂渗透引起材料松驰膨胀,在模型中引入了刻画应力应变关系的弹性体方程.用摄动方法对方程进行了求解.利用溶胀界面数和扩散德伯拉数,对不同机理控制下的介质移动过程和药物释放过程,特别对材料松驰控制的过程进行了分析.
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| 关 键 词： | 可溶胀高分子材料 药物释放 模型 弹性体 |
MODEL OF DRUG CONTROLLED RELEASE FROM SWELLABLE POLYMER |
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| Li Lingbing,Chen Shenglan. MODEL OF DRUG CONTROLLED RELEASE FROM SWELLABLE POLYMER[J]. Journal Of Blomedical Englneerlng Research, 2001, 20(4): 5-10 |
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| Authors: | Li Lingbing Chen Shenglan |
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| Abstract: | The mechanism of drug release from swellable polymer was studied.The model which can explain the drug release from glassy polymer was developed by coupling drug diffusion equation and solvent diffusion equation. The effect of viscoelestic stress of polymer was also considered. The Deborah number and swelling interface number were used to describe the mechanism of drug release,especially relax controlled mechanism. |
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| Keywords: | Swellable polymer Model Controlled release Viscoelastic stress |
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