CO2点阵激光联合萘替芬酮康唑乳膏治疗甲真菌病疗效评价

目的：评价CO₂点阵激光联合萘替芬酮康唑乳膏外用治疗甲真菌病的临床疗效。方法：对2017年1月至2018年8月我科门诊甲真菌病患者患甲进行CO₂点阵激光照射（2周1次），每日外涂萘替芬酮康唑乳膏治疗，共治疗16周。观察临床疗效、真菌学检查结果及不良反应发生情况。结果：共治疗35例患者，35个靶甲，其中指甲5个，趾甲30个；白色浅表型8个，远端侧位甲下型18个，近端甲下型9个。在第4次治疗后有效率为54.29%，真菌清除率为74.29%；疗程结束3个月后有效率为82.89%，真菌清除率为88.57%。结论：CO₂点阵激光联合萘替芬酮康唑乳膏治疗甲真菌病安全有效。

Clinical efficacy of carbon-dioxide fractional laser combined with naftifene ketoconazole cream in the treatment of onychomycosis

Objective:To assess the clinical efficacy of carbon-dioxide fractional laser combined with naftifene ketoconazole cream in the treatment of onychomycosis.Methods:The onychomycosis patients from Jan,2017 to Aug,2018 were treated with CO 2 fractional laser once every 2 weeks and topical naftifene ketoconazole cream everyday for 16 weeks.The efficacy,fungal clearance rate and side effects of every patients were assessed.Results:Thirty-five patients with 35 nails,including 5 fingernails and 30 were treated.Of 35 nails,8 were superficial white onychomycosis,18 were distal and lateral subungual onychomycosis,and 9 were proximal subungual onychomycosis.The efficiency and fungal clearance rate were 54.29%and 74.29%after treatment for 4 times,while the efficiency and fungal clearance rate were 82.89%and 88.57%at the third month after the end of treatment.Conclusion:CO 2 fractional laser combined with naftifene ketoconazole cream is effective and safe in treating onchomycosis.