环境微细颗粒物与过敏性皮肤病关系的Meta分析

目的：定量评估环境微细颗粒物PM10、PM2.5与过敏性皮肤病的关系。方法：检索国内外文献数据库，系统收集相关文献并提取效应量。使用 RevMan 5.3和Stata 14.2软件对文献进行Meta分析，根据异质性结果进行亚组分析和敏感性分析，并检验发表偏倚及校正合并效应量。结果：共纳入25篇文献；PM10、PM2.5每增高10 μg/m3，对过敏性皮肤病影响的合并效应量分别为1.0049（95% CI：1.0016~1.0081）与1.0066（95% CI：1.0033~1.0100）；亚组分析显示PM10和PM2.5对特应性皮炎影响的合并效应量分别为1.0108（95% CI：0.9999~1.0219）、1.0320（95% CI：1.0056~1.0590），对湿疹影响的合并效应量分别为1.0040（95% CI：1.0006~1.0075）、1.0066（95% CI：1.0029~1.0103）；PM2.5对荨麻疹影响的合并效应量为0.9994（95% CI：0.9852 ~1.0139）。结论：环境微细颗粒物与过敏性皮肤病发生相关，PM10和PM2.5浓度升高会增加特应性皮炎和湿疹的发生风险。

Relationship between environmental fine particulate matter and allergic skin diseases:a meta-analysis

Objective:To quantitatively evaluate the relationship between environmental PM 10 or PM 2.5 and allergic skin diseases.Methods:Domestic and international databases were retrieved online,and related literature was collected systematically.Meta-analysis was performed using RveMan 5.3 and Stata 14.2 version,and the sensitivity and subgroup analysis were performed based on the results of heterogeneity.The publication bias was furtherly tested and corrected.Results:A total of 25 studies were included.As an increase of environmental PM 10 and PM 2.5 in per 10μg/m3,the combined effect values on allergic skin diseases would be increased by 1.0049(95%CI:1.0016-1.0081)and 1.0066(95%CI:1.0033-1.0100),respectively.Subgroup analysis showed the combined effect values of PM 10 and PM 2.5 on atopic dermatitis were 1.0108(95%CI:0.9999-1.0219)and 1.0320(95%CI:1.0056-1.0590).The combined effect values of PM 10 and PM 2.5 on eczema were 1.0040(95%CI:1.0006-1.0075)and 1.0066(95%CI:1.0029-1.0103),and the combined effect value of PM 2.5 on urticaria was 0.9994(95%CI:0.9852-1.0139).Conclusion:Environmental fine particulate matter is positively associated with allergic skin diseases,and as an increase in concentrations of PM 10 and PM 2.5 the risk of development of atopic dermatitis and eczema will be elevated.