嗜酸性粒细胞增多综合征一例并文献复习

患者，男，79岁。全身皮肤弥漫性潮红、脱屑，咳嗽、气短3个月。多次外周血EC均>1.5×10⁹/L，皮肤活检示海绵水肿性浅层血管周围炎，浸润细胞为嗜酸粒细胞、淋巴细胞。支气管镜活检示支气管黏膜及肺泡间隔内可见少量嗜酸粒细胞浸润。结合临床表现、实验室检查及组织病理改变可明确诊断为嗜酸性粒细胞增多综合征伴皮肤和肺部受累。给予泼尼松75 mg/d，病情逐渐好转。

Hypereosinophilic syndrome: a case report and literature review

A 79-year-old male presented with edematous erythema all over the body, cough, shortness of breath for 3 months. Repeated blood tests showed eosinophilic count >1.5×10⁹/L. Skin biopsy showed spongiotic perivascular inflammation with eosinophils and lymphocytes in the superficial dermis. Bronchoscopic biopsy showed eosinophilic infiltrates in tunica mucosa bronchiorum and alveolar septae. According to the clinical manifestation, laboratory examination and histopathological changes, the diagnosis of hypereosinophilic syndrome was made. The patient was treated with oral prednisolone at a dose of 75 mg once a day, and his cutaneous lesions and lung symptoms improved.