| S-100阳性泛发性幼年黄色肉芽肿一例并文献复习 |
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| 引用本文： | 张晶,晏洪波,黄长征. S-100阳性泛发性幼年黄色肉芽肿一例并文献复习[J]. 中国麻风皮肤病杂志, 2020, 36(1): 32-34. DOI: 10.12144/zgmfskin202001032 |
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| 作者姓名： | 张晶 晏洪波 黄长征 |
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| 作者单位： | 1中国人民解放军中部战区总医院皮肤科，武汉，430072；2华中科技大学同济医学院附属协和医院皮肤科，武汉，430022 |
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| 摘 要： | 报道1例S-100阳性泛发性幼年黄色肉芽肿患儿并对相关文献进行复习。患儿，男，6个月，面部、躯干、四肢起疹3个月余。组织病理示：表皮基本正常，真皮内可见团块状结节性浸润，浸润细胞主要为泡沫样组织细胞，梭形组织样细胞，并可见Touton巨细胞。免疫组化：泡沫样组织细胞及梭形组织样细胞CD68(+)，S-100(+)，CD1a(-)，Langerin（-）；电镜检查示：未见Birbeck颗粒。诊断：泛发性黄色肉芽肿。
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| 关 键 词： | 泛发性黄色肉芽肿 S-100蛋白 |
Generalized juvenile xanthogranuloma with S-100 positive:a case report and literature review |
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| ZHANG Jing,YAN Hongbo,HUANG Changzheng. Generalized juvenile xanthogranuloma with S-100 positive:a case report and literature review[J]. China Journal of Leprosy and Skin Diseases, 2020, 36(1): 32-34. DOI: 10.12144/zgmfskin202001032 |
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| Authors: | ZHANG Jing YAN Hongbo HUANG Changzheng |
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| Affiliation: | 1 Department of Dermatology, General Hospital of Central Theater Command, Chinese Peoples Liberation Army, Wuhan 430072, China; 2 Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China |
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| Abstract: | A 6-month-old male infant with generalized juvenile xanthogranuloma was reported and related literature was reviewed.The infant presented with a 3-month history of brown-yellow papules scattered on the face,trunk and extremities.Skin biopsy showed a dermal infiltrate of many histiocytes,foam cell and Touton giant cell,eosinophilic granulocytes and a small number of lymphocytes.Immunohistochemical examination of the lesions showed positive staining for CD68,S-100 and negative for CD1a and langerin antibodie.Birbeck granules was not found under electron microscope.The diagnosis of generalized juvenile xanthogranuloma was made. |
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| Keywords: | generalized xanthogranuloma S-100 protein |
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