595 nm脉冲染料激光治疗婴幼儿面部和四肢浅表血管瘤的疗效比较

目的:比较595 nm脉冲染料激光治疗婴幼儿面部及四肢浅表血管瘤的疗效及不良反应。方法:回顾性分析我科2017年12月至2020年1月收治的浅表血管瘤患者的临床资料,分为累及面部(面部组)和累及四肢(四肢组)两组。疗效评估由监护人和未参与治疗的皮肤科医生通过比较治疗前后病变照片共同完成。治疗效果分为:痊愈、显效、有效、无效,皮损大小和颜色改善分别为≥90%,60%~89%,30%~59%,<30%或病变扩大。结果:共91例浅表血管瘤患者纳入分析,其中面部组43例,四肢组48例。面部组和四肢组分别有53.5%和72.9%的患者达到痊愈,分别有86%和100%患者皮损达到有效,两组间痊愈率和有效率差异均有统计学意义(均P<0.05)。面部组和肢体组的不良反应发生率分别为23.3%和16.7%,差异无统计学意义(P>0.05)。结论:595 nm脉冲染料激光治疗四肢浅表血管瘤疗效优于面部,不良反应无明显差异。

Comparing of efficacy of 595 nm pulsed dye laser treatment for superficial hemangiomas on face and limbs of infants

Objective: To compare the efficacy and adverse reactions of 595 nm pulsed dye laser (PDL) in the treatment of superficial hemangiomas (SH) on the face and limbs of infants. Methods: The clinical data of infants with SH treated with 595 nm PDL in our department from December 2017 to January 2020 were analyzed retrospectively. The patients, with hemangioma were divided into face group and  limbs group according to the lesion locaton. Evaluation of the efficacy was completed collectively by the guardians, and senior dermatologists who did not participate in the treatment by comparing the change of the lesion in the photos before and after treatment. The clinical response to treatment was classified as cure, significant improvement, improvement and no improvement, when there was a greater than 90%, 60%-89%, 30%-59%, <30% reduction in the coloration and hemangioma size respectively. Results: Totally, 91 patients with hemangioma were involved in the study while 43 patients were in the face group and 48 patients were in the limbs group. The cure rates were 53.5% and 72.9% in face group and limbs group respectively with significant differences (P<0.05). The improvement rates were 86% and 100% respectively in face group and limbs group with significant differences (P<0.05). The rates of adverse effect were 23.3% and 16.7% in face group and limbs group respectively, with no significant difference (P>0.05). Conclusion: 595 nm PDL in the treatment of superficial hemangioma on limbs is more effective than on face, with no significant difference of the adverse reaction in the two groups.