Subcellular localization of hexokinase in the rat cortex |
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| Authors: | P. Teichgraber D. Biesold Z. D. Pigareva |
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| Affiliation: | (1) Neurochemical Department, Karl Marx University, Leipzig, East Germany;(2) Laboratory of Biohistochemistry, Brain Institute, USSR Academy of Medical Sciences, Moscow |
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| Abstract: | The distribution of hexokinase, inactivated and activated by Triton X-100, in subcellular fractions of the rat cortex was investigated. Latent hexokinase, inactivated and activated by the detergent Triton X-100 in the mitochondria is confirmed by the parallel distribution of cytochrome oxidase and hexokinase activities. Specific hexokinase activity of the external mitochondrial membrane was almost twice as high as that of the internal membrane. The existence of a special molecular form of latent hexokinase is discussed.We are grateful to technical assistants R. Arnold and I. Scheel for their help. The investigation was financially supported by the Ministry of Science and Technology of the GDR. |
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