| 鸦胆子种子化学成分的研究 |
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| 引用本文： | 王群,杨勇勋,刘庆鑫,张建平,陈利萍,李慧梁,管淑玉. 鸦胆子种子化学成分的研究[J]. 中草药, 2015, 46(19): 2839-2842 |
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| 作者姓名： | 王群 杨勇勋 刘庆鑫 张建平 陈利萍 李慧梁 管淑玉 |
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| 作者单位： | 广东药学院中药学院, 广东 广州 510006;第二军医大学药学院, 上海 200433;第二军医大学药学院, 上海 200433;第二军医大学药学院, 上海 200433;第二军医大学药学院, 上海 200433;第二军医大学药学院, 上海 200433;第二军医大学药学院, 上海 200433;广东药学院中药学院, 广东 广州 510006;国家中医药管理局中药数字化质量评价技术重点研究室, 广东 广州 510006;广东高校中药质量工程技术研究中心, 广东 广州 510006 |
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| 基金项目： | 国家自然科学基金资助项目(81102335) |
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| 摘 要： | 目的研究鸦胆子Brucea javanica种子的化学成分。方法运用硅胶色谱、ODS、Sephadex LH-20等色谱方法进行分离纯化,结合高分辨质谱和核磁共振波谱分析鉴定化合物的结构。结果从鸦胆子种子90%乙醇提取物中分离得到5个苦木内酯类化合物,分别鉴定为鸦胆子内酯W(1)、yadanziolide A(2)、鸦胆子苦素D(3)、鸦胆子苦素E(4)、javanicolide A(5)。结论化合物1为未见文献报道的新化合物。
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| 关 键 词： | 鸦胆子 苦木内酯 鸦胆子内酯W yadanziolide A 鸦胆子苦素D |
| 收稿时间： | 2015-07-01 |
Study on chemical constituents from seeds of Bruceae Fructus |
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| WANG Qun,YANG Yong-xun,LIU Qing-xin,ZHANG Jian-ping,CHEN Li-ping,LI Hui-liang and GUAN Shu-yu. Study on chemical constituents from seeds of Bruceae Fructus[J]. Chinese Traditional and Herbal Drugs, 2015, 46(19): 2839-2842 |
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| Authors: | WANG Qun YANG Yong-xun LIU Qing-xin ZHANG Jian-ping CHEN Li-ping LI Hui-liang GUAN Shu-yu |
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| Affiliation: | School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China;School of Pharmacy, Second Military Medical University, Shanghai 200433, China;School of Pharmacy, Second Military Medical University, Shanghai 200433, China;School of Pharmacy, Second Military Medical University, Shanghai 200433, China;School of Pharmacy, Second Military Medical University, Shanghai 200433, China;School of Pharmacy, Second Military Medical University, Shanghai 200433, China;School of Pharmacy, Second Military Medical University, Shanghai 200433, China;School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China;Key Laboratory of Digital Quality Evaluation of Chinese Materia Medica of State Administration of TCM, Guangzhou 510006, China;Engineering Technology Research Center for Chinese Materia Medica Quality of the Universities of Guangdong Province, Guangzhou 510006, China |
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| Abstract: | Objective To investigate the chemical constituents from Bruceae Fructus (the seeds of Brucea javanica). Methods These compounds were isolated by means of silica gel, ODS, Sephadex LH-20 column chromatographies. Their structures were identified by the methods of high resolution mass spectrometry (HRMS) and NMR spectroscopic analyses. Results Five quassinoids were isolated from 90% ethanol extract in Bruceae Fructus and identified as yadanziolide W (1), yadanziolide A (2), bruceine D (3), bruceine E (4), javanicolide A (5), respectively. Conclusion Compound 1 is a new quassinoid which has not been reported in literature. |
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| Keywords: | Brucea javanica (L.) Merr. quassinoids yadanziolide W yadanziolide A bruceine D |
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