氢质子磁共振波谱在一氧化碳中毒迟发性脑病诊断中的应用

目的探讨氢质子磁共振波谱（1H—MRS）各参数峰下面积在一氧化碳中毒后迟发性脑病的诊断价值。方法将研究对象分为两组，即临床拟诊的一氧化碳中毒迟发性脑病（DNS）组38例，健康对照组18例，对研究对象分别进行常规核磁共振成像（MRI）和激励回波采集（STEAM）检查，测量各感兴趣区化合物的峰下面积。结果获取的患者波谱数据显示N-乙酰天门冬氨酸（NAA）（881±76），胆碱（Cho）（2352±86），B、1谷氨酸类化合物（β、γGlx）（3024±187），与对照组比较B、7Glx及Cho升高，但NAA降低，DNS组与对照组NAA、Cho、β、γGlx有显著差异（P〈0．05）；同时发现在0．9—1．40ppm间Lip峰值升高，峰下面积增加。结论。H-MRS的测定可能会在一定程度上协助急性一氧化碳中毒后迟发性脑病的诊断。

Application of magnetic resonance spectroscopy in diagnosing DNS

Objkctive To determine the potential ability of the area of each peak for the proton magnetic resonance spectroscopy(1 H-MRS) in the diagnosis of DNS(Delayed neuropsychological sequelae after carbon monoxide poisoning).Methods MRI and STEAM(stimulated-echo-acquisition mode)were performed in 38 DNS patients and 18 healthy volunteers.The area of the peak of each organic compound were obtained in each volume of interest.Results The data spectra abtained from patients shows NAA(881±76),Cho(2 352 ±86),β、γGlx(3 024 ± 187).Compared with the control group,theβ、γGlx ratio and Cho area increased,but the NAA ratio decreased.The area of NAA,Cho,β、γGlx between DNS and control group were compared,the results showed significant differences (P ＜0.05).In spectroscopy,the Lip evaluated peak in 0.9～1.40 ppm were detected.Conclusion 1H-MRS may do some contribution to the diagnosis of DNS.