Variability in the pharmacokinetics of cyclophosphamide,methotrexate and 5-fluorouracil in women receiving adjuvant treatment for breast cancer |
| |
| Authors: | M. J. Moore C. Erlichman J. J. Thiessen P. S. Bunting R. Hardy I. Kerr S. Soldin |
| |
| Affiliation: | (1) Department of Medicine, Princess Margaret Hospital, University of Toronto, 500 Sherbourne Street, Toronto, Ontario, Canada;(2) Departments of Pharmacology, Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada;(3) Departments of Medicine and Pharmacology, Toronto Bayview Regional Cancer Centre, Mississauga, Ontario, Canada;(4) Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada;(5) Department of Clinical Biochemistry, University of Toronto, Toronto, Ontario, Canada |
| |
| Abstract: | A total of 23 women with stage II breast cancer receiving adjuvant cyclophosphamide, methotrexate and 5-fluorouracil had detailed pharmacokinetic monitoring performed on the first and third courses of therapy. The area under the concentration time curve (AUC) of each of these three drugs varied by a factor of 3–4 among patients. No systematic change in pharmacokinetics between the first and third courses was seen for cyclophosphamide, methotrexate or 5-fluorouracil, and the mean AUC for each of the three drugs did not change. However, significant intrapatient variability in drug pharmacokinetics was observed for all three drugs such that the AUC, clearance and half-life in an individual on the third course could not be reliably predicted from data generated on the first course. On the basis of these results, cyclophosphamide, methotrexate, and 5-fluorouracil pharmacokinetic data from one treatment would not be useful information from which the doses for subsequent courses could be determined.This research was supported by the National Cancer Institute of Canada |
| |
| Keywords: | Ether lipid ET-18-OCH3 Cell kill Drug dose |
| 本文献已被 SpringerLink 等数据库收录！ |
|
