| 侧脑室注射前列腺素E_2升压效应机理的初步探讨 |
| |
| 引用本文： | 林童俊,刘菊芳.侧脑室注射前列腺素E_2升压效应机理的初步探讨[J].南方医科大学学报,1987(Z1). |
| |
| 作者姓名： | 林童俊 刘菊芳 |
| |
| 作者单位： | 第一军医大学药理学教研室，第一军医大学药理学教研室 指导教师 |
| |
| 摘 要： | 侧脑室注射前列腺素E_2(PGE_2)引起动脉血压升高,其升压效应可部分地被6—羟基多巴胺或酚妥拉明阻断;这两种药物联合使用可完全阻断升压效应.育亨宾、哌唑嗪和心得安对PGE_2升压效应无影响.中枢PGE_2升压效应与肾上腺素α、β受体无直接联系;可能与肾上腺素能神经突触前膜和突触后膜分别存在的两类不同性质的作用点有关。
|
| 关 键 词： | 前列腺素E_2 侧脑室 血压 6-羟基多巴胺 酚妥拉明 育亨宾 唑哌嗪 心得安 受体 |
Preliminary study on the mechanism of the hypertensive effects of intracerebroventricularly administeredprostaglandin E_2 |
| |
| Lin Tongjun.Preliminary study on the mechanism of the hypertensive effects of intracerebroventricularly administeredprostaglandin E_2[J].Journal of Southern Medical University,1987(Z1). |
| |
| Authors: | Lin Tongjun |
| |
| Institution: | Department of Pharmacology |
| |
| Abstract: | Effect of intracerebroventricularly(icv ) administered prostaglandin E2(PGE2) on blood pressure was studied in anaesthetized Sprague-Dawley rats-The hypertensive effect induced by icv injection of PG E2 was partly inhibited by 6-hydro-xydopamne or phentolamine and totally inhibited by the combination of both of them, but not by prazosin, yohimbine or propranolol. These findings suggest that the central hypertensive effect of PG E2 is unrelated to the adrenergic or receptors. Probably there are two different kinds of action sites on the pre-and post-s ynaptic membranes of adrenergic nerve separately. |
| |
| Keywords: | prostaglandin E cerebroventricle 6-hydroxydopaminephentolamine yohimbine prazosin propranololblood pressure receptor |
| 本文献已被 CNKI 等数据库收录！ |
