羟丙基甲基纤维素骨架片的水渗透、骨架膨胀和药物释放性质

当HPMC骨架与水接触时，可以观察到水渗透进入HPMC骨架的过程。HPMC取代度类型对水渗透作用的影响集中表现在最初较短的一段时间内，这段时间是指HPMC形成水凝胶的时间。水凝胶形成后，水渗透进入凝胶的速率是恒定的。HPMC对水渗透作用的影响取决于其分子量。当HPMC骨架中加入药物后，水渗透进入骨架的能力会变弱。当水渗透进入HPMC骨架时，骨架可发生明显的膨胀，其轴向膨胀比径向膨胀大得多，骨架的膨胀主要由HPMC产生，骨架中HPMC含量越高，其膨胀程度越大。水渗透、骨架膨胀与药物释放之间存在线性相关性。

Water Penetration, Matrix Swell and Drug Release Property Studies of Hydroxypropylmethyl Cellulose Matrix Tablets

Water penetration into HPMC matrices may be observed when they are brought into contact with water. The effects of HPMC substitute type on the water penetration are concentrated on the initially short time, which is considered to be the time for HPMC to form a hydrogel. After hydrogel is formed, the water penetration rate is identical. The effect of HPMC on water penetration depends on its molecular weight. When a drug is added into HPMC matrix, the ability of water penetration into matrix is weakened. As the water penetrates, a considerable swelling of the HPMC matrix is also observed, axial swelling is greater than radial swelling, and the swelling of matrix is mainly produced by HPMC. High HPMC level produces large swelling of matrix. Linear relations exist between water penetration, matrix swelling and drug release.