| Cyclaradine的抗单纯疱疹病毒作用:在体和离体实验研究 |
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| 引用本文： | 袁非,黎蕾,王历阳. Cyclaradine的抗单纯疱疹病毒作用:在体和离体实验研究[J]. 眼科新进展, 2003, 23(1): 17-19 |
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| 作者姓名： | 袁非 黎蕾 王历阳 |
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| 作者单位： | 1. 200032,上海,复旦大学附属中山医院眼科
2. 复旦大学附属眼耳鼻喉科医院眼科 |
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| 摘 要： | 目的 探讨(十)—Cyclaradine在体外及动物模型中抗HSV—1及其耐药株的作用。方法 应用VER0细胞培养和实验性单纯疱疹病毒性角膜炎动物模型，观察(十)—Cyclaradine对HSV—1KOS株、F株、HFTC株、dPyK株、7—2667ACVr株和LeBleu株的抑制效果，并与无环鸟苷(acyclovir，ACV)和三氟胸苷(trif1uorothymidine，TFT)作比较。结果 (十)—Cyclaradine在体外及动物模型中有确切的抗HSV—1作用，而且对ACV和TFT的耐药株也同样有效。结论 (十)—Cyclaradine是一种值得进一步研究的治疗单纯疱疹病毒性角膜灸的药物。
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| 关 键 词： | Cyclaradine 角膜炎 单纯疱疹病毒 耐药性 抗病毒药 细胞培养 |
| 文章编号： | 1003-5141(2003)01-0017-03 |
| 修稿时间： | 2002-07-29 |
Activity of (+)-Cyclaradine against herpes simplex virus 1:in vivo and in vitro studies |
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| YUAN Fei,LI Lei,WANG Li Yang. Activity of (+)-Cyclaradine against herpes simplex virus 1:in vivo and in vitro studies[J]. Recent Advances in Ophthalmology, 2003, 23(1): 17-19 |
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| Authors: | YUAN Fei LI Lei WANG Li Yang |
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| Abstract: | Objective To evaluate the activities of (+) Cyclaradine against herpes simplex virus 1 (HSV 1) in vitro and in vivo . Methods Comparative tests were carried out in VERO cell line and rabbit eyes with the strains of HSV 1 resistance and nonresistance to acyclovir (ACV) and trifluorothymidine(TFT) by the (+) Cyclaradine, ACV and TFT.Results (+) Cyclaradine was active against HSV 1 and TK ACV resistant mutants.Conclusion (+) Cyclaradine is potentially one of the alternative agents for the therapy of herpes simplex keratitis, especially, in the cases of virus strains of drug resistance to the antiviral agents now is available in market. |
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| Keywords: | (+)-Cyclaradine herpes simplex virus keratitis |
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