抗CCP抗体与RF联合检测在类风湿关节炎中的诊断价值

目的探讨抗环瓜氨酸肽（CCP）抗体和类风湿因子（RF）检测在类风湿关节炎（RA）诊断中的意义。方法用ELISA方法检测108例（RA62例，非RA46例，及正常人30例）血清中的抗CCP抗体，免疫比浊法测RF，并比较抗CCP抗体与RF对于RA的敏感性和特异性。结果抗CCP抗体在RA组患者血清中的阳性率51．8％，明显高于非RA组（3．21％）和正常对照组（0．0％），经t检验P〈0．05。抗CCP抗体对诊断RA的敏感性和特异性分别为50．1％、46．2％，在62例确诊为RA患者的血清中抗CCP抗体与RF重叠阳性率为55．1％，两者含量呈正相关。结论抗CCP抗体对RA具有很高的特异性，可视为新的RA血清学诊断指标，它与RA联合检测更能提高RA的早期诊断率.

Diagnostic Value of Anti-cyclic Citrullinated Peptide Antibody and RheumatoidFacter in Patients with Rheumatoid Arthritis

Objective To explore the significance of CCP antibody and rheumatoid facter in the diagnosis orheumatoid arthritis. Methods Anti CCP antibody from the 108 eases was detect by enzyme - linked immu - nosorbent assay （62 cases were rheumatoid arthritis,46 cases were non- rheumatoid arthritis and 30 case were normal ） and RF by immunoturbidimetric assay. The relativity between antibody against CCP antibodand RF was compared. Results The positive rate of antibody against CCP antibody of the RA group was 51.1% and was significantly higher than that of the non- RA group（3.21% ） and that of the control group（00%, P 〈 0.05）. The sensitivity and specificity were 50.1%, 46.2% respectively. The cross positive of CCPantibody and RF in RA group of 62 cases was 55.1%. Their quantity was positively related. Conclusion The CCP antibody might have very high specificity and might be used as a valuable parameter in the diagno - sis of rheumatoid arthritis.