不同时辰中药保留灌肠对慢性肾衰竭患者的影响

目的：探讨不同时辰中药保留灌肠对药物保留时间及慢性肾衰竭患者的影响。方法将60例慢性肾衰竭患者按随机数字表法分为观察组（30例）和对照组（30例）。观察组在辰时（7：00—9：00）进行灌肠，对照组在常规时间戌时（19：00—21：00）进行灌肠。比较两组患者的主观感受和不良反应、灌肠前排便率、灌肠后出现便意感程度、灌肠后药物保留时间、灌肠前后血肌酐（ Scr ）、尿素氮（ BUN）、尿酸（ Ua）的变化。观察周期为30 d（1个疗程）。结果观察组腹痛、腹胀、肛门疼痛、肛门坠迫感与对照组相比减轻，差异有统计学意义（P＜0．05）；观察组灌肠后出现便意感的人次数及程度显著低于对照组，差异有统计学意义（P＜0．05）；灌肠前平均排便率观察组为83．3％，对照组为20．0％，差异有统计学意义（χ2＝79．452，P＜0．01）；药物保留时间观察组为（324．12±129．47）min，对照组为（225．32±104．21）min，差异有统计学意义（t＝4．605，P＜0．01）；两组患者灌肠后血BUN、Scr、Ua较治疗前降低，但观察组优于对照组，差异有统计学意义（P＜0．05）。结论辰时（7：00—9：00）中药保留灌肠可以增加药物在肠道内的保留时间并可提高中药保留灌肠对慢性肾衰竭患者的疗效。

Effect of retention enema with Chinese Traditional Medicine at different hour on the patients with chronic renal failure

Objective To study the impact of medicine retention time and the therapeutic effect to the chronic renal failure by retention enema with Chinese traditional Medicine at different hour.Methods Totals of 60 patients with chronic renal failure disease were randomly divided into observation group （n=30）and control group （n=30）.The observation group adopted enema at 7：00-9：00, and the control group adopted enema at routine hour （ 19：00 -21：00 ） .Following items were observed and compared between two groups： subjective feeling, adverse reflection, defecating ratio before enema, the appetency of defecating after enema, medicine retention time after enema, the Scr before and after enema, the change of BUN and Ua.The observation period was 30 days （ one period of the treatment） .Results Compared with the control group, the adverse reflection, such as bellyache, abdominal distension, anus ache, downfallen pressure feeling at anus were significantly relieved in observation group （P〈0.05）.The times ＆amp; severity of the appetency of defecating after enema in observation group was reduced apparently than that in control group （P〈0.05）.The average defecating ratio before enema in observation group was significantly improved （83.3%vs 20.0%;χ2 =79.452,P〈0.01）.The retention time in observation group was （ 324.12 ±129.47 ） min, and that in control group was （ 225.32 ± 104.21）min,and the difference was statistically significant （t=4.605,P〈0.01）.The blood BUN, Scr, Ua were down after enema in both groups, but the improvement in observation group was significantly better than that in the control group （P 〈0.05）.Conclusions By practicing retention enema with Chinese traditional Medicine at 7：00-9：00, the medicine retention time in intestines can be extended, and the therapeutic effect to the chronic renal failure can be improved.