丹参川芎嗪注射液治疗放射性肺损伤的疗效及其机制研究

目的观察丹参川芎嗪注射液对于胸部放疗后患者肺损伤发生率及血浆TGF-β1、TNF-α的影响。方法 112例患者分为两组,治疗组(丹参川芎嗪注射液+放疗)58例,对照组(放疗)54例,观察两组治疗前后血浆TGF-β1、TNF-α的变化以及治疗后放射性肺损伤的发生率。结果治疗前两组血浆TGF-β1、TNF-α含量比较无明显差异;治疗后治疗组较对照组明显降低,差异有统计学意义(P0.05)。治疗组放射性肺损伤的发生率较对照组减少。结论丹参川芎嗪注射液可减少放疗后患者血浆TGF-β1、TNF-α的升高幅度,预防急性放射性肺炎和放射性肺纤维化有一定的疗效,具有较好的安全性。

Effects of Salvia Ligustrazine Injection on Radiation-induced Lung Injury Patients

Objective Salvia ligustrazine injection on patients after thoracic radiotherapy for lung injury incidence and plasma TGF - β1, TNF-α effect. Methods 112 patients were divided into two groups , the treatment group （ Salvia lignstrazine injection plus radio- therapy ） 58 cases in the control group （ radiotherapy ） 54 cases were observed before and after treatment plasma TGF - β1, TNF - α and changes in treatment after the incidence of radiation - induced lung injury . Results Before treatment, plasma TGF - β1, TNF - α levels showed no significant difference ; treatment group was significantly lower than the control group , the difference was statistically significant （P 〈 O. 05）. Treated group the incidence of radiation - induced lung injury than the control group decreased. Conclusion salvia ligustrazine injection in patients after radiotherapy can reduce plasma TGF - β1, TNF - α is increased range , the prevention of acute radiation pneumo- nitis and radiation pulmonary fibrosis have a certain effect , with better security.