三清降糖缓释片对糖尿病兔胰岛素抵抗的影响

目的：观察三清降糖缓释片对糖尿病兔胰岛素抵抗的影响。方法将40只健康成年雄性家兔随机分为5组，即空白对照组、模型对照组、格列美脲片组、三清降糖汤剂组和三清降糖缓释片组，每组8只。空白对照组予普通饲料喂养，其余4组均予普通饲料＋高脂高糖饲料喂养，制备糖尿病模型。空白对照组、模型对照组予纯净水灌胃，三清降糖汤组予三清降糖汤混悬液灌胃，三清降糖缓释片组予三清降糖缓释片整片服用，格列美脲片组予格列美脲片整片服用。于给药4周末，观察各组空腹血糖（ FPG）、血脂[总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）]、血清胰岛素（FINS）及肿瘤坏死因子α（TNF-α）变化。结果模型对照组FPG、FINS、胰岛素抵抗指数（HOMA-IR）及TNF-α均较空白对照组升高（P＜0．01），说明造模成功；与模型对照组比较，格列美脲片组、三清降糖汤组及三清降糖缓释片组FPG、FINS、HOMA-IR及TNF-α均下降（P＜0．05）。模型对照组TG、TC及LDL-C均高于空白对照组（P＜0．01），HDL-C低于空白对照组（P＜0．01）。与模型对照组比较，格列美脲片组、三清降糖汤组及三清降糖缓释片组TG、TC及LDL-C 均降低（P＜0．05），HDL-C升高（P＜0．05）。结论三清降糖缓释片对糖尿病兔具有降血糖、降血脂作用。

Effects of sustained -release Sanqingjiangtang tablet on insulin resistance in diabetic rabbits

Objective To observe the effect of sustained -release Sanqingjiangtang tablets on insulin resist-ance in diabetic rabbits .Methods To induce diabetes in healthy male rabbits by high fat sugar and high salt diet , and then inject streptozotocin （STZ）.50 healthy male rabbits were divided into5 groups randomly, control group, model group , glimepiride group ,Sanqingjiangtang decoction and sustained -release tablets group .Intragastric admin-istration of the corresponding drugs respectively for 4 weeks,and then measuring blood glucose , blood lipid, insulin, TNF-αand calculating HOMA -IR.Results FPG, FINS, HOMA-IR and TNF-αin model group were in-creased as compared with those in control group （P〈0.01）.FPG, FINS, HOMA-IR and TNF-αin glimepiride group,Sanqingjiangtang decoction and sustained -release tablets group were decreased as compared with those in model group （P〈0.05）.The levels of TG, TC and LDL-C in model group were higher than those in control group （P〈0.01）.HDL-C in model group was lower （P〈0.01）.The levels of TG, TC and LDL-C in glimepiride group,Sanqingjiangtang decoction and sustained -release tablets group were lower than those in model group （ P〈0.05）.HDL-C was higher （P〈0.05）.Conclusion Sanqingjiangtang sustained -release tablets can significantly decrease blood lipid and glucose in diabetic rabbits .