| HBsAg阳性孕妇及新生儿HBV复制状况的研究 |
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| 引用本文： | 史晓红,王素萍,李淑珍,解良娟,冯丽萍,双杰玉. HBsAg阳性孕妇及新生儿HBV复制状况的研究[J]. 中国公共卫生, 2004, 20(5): 513-514 |
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| 作者姓名： | 史晓红 王素萍 李淑珍 解良娟 冯丽萍 双杰玉 |
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| 作者单位： | 1. 山西医科大学流行病学教研室,太原,030001
2. 太原市传染病医院妇产科 |
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| 基金项目： | 20 0 0年国家自然科学基金资助 (30 0 70 699) |
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| 摘 要： | 目的 探讨HBsAg阳性孕妇及其新生儿外周血单个核细胞乙肝病毒(PBMCHBV)复制状况。方法 收集2001年6月～2002年12月由太原市传染病院妇产科进行产前检查井分娩的151例HBsAg阳性孕妇及其153例新生儿．用选择性聚合酶链反应技术进行PBMC HBV rcDNA与PBMC HBV cccDNA的检测。结果 HBsAR阳性孕妇PBMC HBV rcDNA的检出率为36.42％(55/151)，PBMC HBV cccDNA的检出率为9.93％(15/151)；新生儿PBMC HBV rcDNA的检出率为22.88％(35/153)，PBMC HBV cccDNA的检出率为4.5B％(7/153)。结论 PBMC为HBV的肝外复制场所，新生儿PBMC HBV复制与其母亲体内PBMC HBV复制有关。
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| 关 键 词： | 乙型肝炎病毒 选择性聚合酶链反应 孕妇 HBsAg |
| 文章编号： | 1001-0580(2004)05-0513-02 |
| 修稿时间： | 2003-09-25 |
Study on replication status of HBsAg positive pregnant women and newborns |
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| SHI Xiao hong,WANG Su ping,LI Shu zhen,et al.. Study on replication status of HBsAg positive pregnant women and newborns[J]. Chinese Journal of Public Health, 2004, 20(5): 513-514 |
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| Authors: | SHI Xiao hong WANG Su ping LI Shu zhen et al. |
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| Affiliation: | SHI Xiao hong,WANG Su ping,LI Shu zhen,et al.Department of Epidemiology,Shanxi Medical University |
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| Abstract: | Objective In order to explore the replication status of PBMC HBV of HBsAg positive pregnant women and their newborns.Methods 151 pregnant women and 153 newborns were collected between 2001 June and 2002 December in Infectious Hospital of Taiyuan city.PBMC HBV DNA were determined by selected polymerase chain reaction (sPCR).Results 15(9.93%) out of 151 HBsAg positive pregnant women had HBV cccDNA in their PBMC,7(4.58%) out of 153 newborns had HBV cccDNA in their PBMC,55(36.42%) out of 151 HBsAg positive pregnant women had HBV rcDNA in their PBMC,35(22.88%) out of 153 newborns had HBV rcDNA in their PBMC.Conclusion PBMC was the replication site of HBV out of liver.PBMC HBV replicatlon of newborns was related to the replication of their mothers. |
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| Keywords: | hepatitis B virus replication selected polymerase chain reaction prenant woman HBsAg |
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