炎见宁致42例不良反应情况分析

目的:分析炎见宁不良反应(ADR)的发生特点、相关因素及临床转归,为临床合理用药提供依据。方法:对2005年1月1日至2015年3月31日以来我院上报的炎见宁ADR报告进行分析汇总,对其发生机制进行探讨。结果:我院炎见宁ADR发生率为0.87%;男性患者发生率稍高于女性患者;50.00%的ADR发生于大于61岁年龄段患者;71.43%的ADR发生于合并用药患者;66.67%的ADR发生于用药4 d以内,且主要表现为皮肤及其附件损害(32.72%);发生严重不良反应3例(包括2例过敏性休克,1例药物性肝炎)。结论:炎见宁的ADR时有发生且发生机制复杂,临床应用时应密切关注患者状态变化,保证用药安全。

Analysis of 42 cases of adverse drug reactions induced by Yanjianning

OBJECTIVE To analyze characteristics of adverse drug reactions (ADR) induced by Yanjianning and to investigate relevant factors and clinical prognosis to provide a reference for rational administration.METHODS A retrospective analysis was performed according to ADRs report forms collected from 2005 to 2015.RESULTS Forty two cases of ADRs induced by Yanjianning were reported. More ADRs were reported in male than in female patients. More ADRs occurred in patients older than 61 years of age, accounting for 50.00%. Drug combination was a risk factor of ADRs. The most common ADRs occurred in skin system (32.72%). ADRs mostly appeared 0-4 days after dosing (66.67%).CONCLUSION Monitoring for ADRs of Yanjianning should be strengthened. Early prevention can reduce the incidence of ADRs.