枸橼酸铋钾、奥美拉唑根除幽门螺杆菌的临床疗效比较

目的　观察枸橼酸铋钾、克拉霉素、替硝唑对幽门螺杆菌 (HP)感染相关性消化性溃疡治疗效果。方法　将经胃镜检查证实的消化性溃疡患者随机分成治疗组 (枸橼酸铋钾 +克拉霉素 +替硝唑 )和对照组 (奥美拉唑 +克拉霉素 +替哨唑 ) ,其中治疗组 72例 ,对照组 70例 ,疗程均为 1周 ,治疗期间记录症状改善情况及不良反应。结果　治疗组痊愈率 4 1.7% ,显效率 38.9% ,总愈合率 80 .6 %。对照组痊愈率 5 7.2 % ,显效率 2 7.1% ,总愈合率 84 .3% ,2组比较 ,总愈合率及愈合后质量差异均无显著意义(P >0 .0 5 )。结论　枸橼酸铋钾、克拉霉素、替硝唑联合用药与奥美拉唑、克拉霉素、替硝唑联合用药 2组疗效接近 (P>0 .0 5 ) ,而前者价格低、疗程短、患者依从性好 ,治疗中无明显不良反应 ,是HP治疗中值得广泛推广的一种方法。

Clinical comparision on the efficacy of bismuth potassium citrate and omeprazole in eradicating Helicobacter pylori

Objectives To observe the efficacy of bismuth potassium citrate and omeprazole and clarithromycin and tinidazole in treatment of helicobacter pylori (HP) infection-related peptic ulcer. Methods 142 patients with peptic ulcer identified by endoscopy were randomly divided into two group.72 patients in treatment group were treated by bismuth potassium citrate,clarithromycin and tinidazole; 70 patients in control group were treated by omeprazole , clarithromycin and tinidazole,with a treatment course of one week.The patient's state of symptom improvement and adverse reaction during the treatment course were observed and recorded. Results The cure rate,effective rate and total healing rate in treatment group were 41.7%,38.9% and 80.6% respectively,which were 57.2%,27.1% and 84.3% respectively in control group. There was no significant difference in total healing rate between two groups (P>0.05).Conclusion The therapeutic effect of bismuth potassium citrate,clarithromycin and tinidazole on HP infection-related peptic ulcer is similar to that of omeprazole, clarithromycin and tinidazole,but the former is comparatively cheaper,with shorter treatment course and less complications.