| 肝纤维化血清标志物在肝病中的诊断价值 |
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| 引用本文： | 卓雪芽,郭冬招,吴英.肝纤维化血清标志物在肝病中的诊断价值[J].国际医药卫生导报,2009,15(3):63-64. |
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| 作者姓名： | 卓雪芽 郭冬招 吴英 |
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| 作者单位： | 佛山市中医院检验科,528000 |
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| 摘 要： | 目的探讨肝纤维化血清标志物在肝病中的诊断价值。方法采用放射免疫分析法（RIA法）检测148例肝病患者的血清Ⅲ型前胶原、Ⅳ型胶原及层粘连蛋白的含量。结果慢活肝、肝硬化、肝癌组的血清Ⅲ型前胶原的含量均显著升高（P〈0．01），而慢迁肝、急性肝炎组升高不明显（P〉0．05）：血清IV型胶原及层粘连蛋白含量在慢性肝炎、肝硬化及肝癌中均有不同程度的升高（P〈0．01），尤以肝硬化组升高显著。结论Ⅲ型前胶原、Ⅳ型胶原及层粘连蛋白血清含量的联合检测可作为监测肝纤维化的发生与发展的较好指标。
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| 关 键 词： | 肝纤维化 Ⅲ型前胶原 Ⅳ型胶原 层粘连蛋白 |
Diagnostic value of serum marker for hepatic fibrosis in patients with hepatic diseases |
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| ZHUO Xue-ya,GUO Dong-zhao,WU Ying.Diagnostic value of serum marker for hepatic fibrosis in patients with hepatic diseases[J].International Medicine & Health Guidance News,2009,15(3):63-64. |
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| Authors: | ZHUO Xue-ya GUO Dong-zhao WU Ying |
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| Institution: | . (Department of Clinical Laboratory, Foshan Hospital of Traditional Chinese Medicine, Foshan 528000, China) |
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| Abstract: | Objective To study the diagnostic value of serum marker for hepatic fibrosis in patients with hepatic diseases,Methods The serum levels of PC Ⅲ,IV-C and LN of 148 patients with various liver diseases were detected by RIA method.Results The serum concertration of PC Ⅲ in patients with CAH,LC,HCC was significantly higher than that in normal control(P 0.05).The serum levels of IV.C and LN were significantly elevated in patients with CPH,CAH,LC and HCC (P
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| Keywords: | Hepatic fibrosis Type IV collagen Laminin |
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