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The role of the Purkinje network in premature ventricular complex-triggered ventricular fibrillation |
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| Authors: | Carola Gianni J David Burkhardt Chintan Trivedi Sanghamitra Mohanty " target="_blank">Andrea Natale |
| Institution: | 1.Texas Cardiac Arrhythmia Institute,St. David’s Medical Center,Austin,USA;2.U.O.C. Cardiologia, IRCCS Ospedale Maggiore Policlinico,University of Milan,Milan,Italy;3.Dell Medical School,University of Texas,Austin,USA;4.Interventional Electrophysiology,Scripps Clinic,La Jolla,USA;5.MetroHealth Medical Center,Case Western Reserve University School of Medicine,Cleveland,USA;6.Division of Cardiology,Stanford University,Stanford,USA;7.Electrophysiology and Arrhythmia Services,California Pacific Medical Center,San Francisco,USA |
| Abstract: | The Purkinje network (PN) is the distal part of the ventricular conduction system, which has shown to play a central role in the pathophysiology of ventricular fibrillation (VF). Abnormal automaticity and triggered activity are commonly seen in the PN, and the resulting premature ventricular complexes (PVCs) are frequently recognized as triggers of this life-threatening arrhythmia. Catheter ablation targeting PN-related PVCs can be successfully performed in patients with medically refractory VF in a variety of arrhythmic substrates. |
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