Chromosomal aberrations in cells of monkeys surviving acute radiation under chemical protection

In the study of the frequency and type of chromosomal aberrations in bone marrow cells and peripheral blood lymphocytes of irradiated monkeys treated 5–10 min before irradiation with the protective compounds 5-methoxytryptamine and 2-aminoethanethiol, etc., showed that 9–10 years after -ray irradiation in doses of 600–650 R the percentage of aberrant chromosomes was significantly higher than the spontaneous level and was at the level of chromosomal changes observed in monkeys irradiated without the use of radioprotectors. In the late period after irradiation, the main type of aberration observed in all monkeys, including those receiving the radioprotectors, was symmetrical chromosomal exchanges.DeceasedPresented by Academician of the Academy of Medical Sciences of the USSR B. A. Lapin.Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 80, No. 8, pp. 109–112, August, 1975.