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| 涎腺腺样囊性癌中端粒酶RNA的表达 | |
| 引用本文： | 陈琰,姜虹,杨连甲,董绍忠,高全文.涎腺腺样囊性癌中端粒酶RNA的表达[J].现代口腔医学杂志,2004,18(2):107-109. |
| 作者姓名： | 陈琰 姜虹 杨连甲 董绍忠 高全文 |
| 作者单位： | 1. 1000853,北京,解放军总医院口腔科 2. 辽河油田中心医院 3. 第四军医大学口腔医学院组织病理教研室 |
| 摘 要： | 目的 研究人端粒酶RNA(hTR)在涎腺腺样囊性癌 (adenoidcysticcarcinoma;ACC)中的表达 ,探讨hTR与细胞增殖之间的关系及其临床意义。方法 采用原位杂交和免疫组化技术检测 19例涎腺ACC和 4例正常涎腺组织标本。结果 涎腺ACC组织中hTR表达显著增高 ( P <0 .0 0 1)且与病理分型有关 ( P <0 .0 5 ) ,hTR表达与PCNA表达间呈正相关 (P <0 .0 5 )。结论 hTR表达可能和涎腺组织增殖恶变有关 |
| 关 键 词： | 涎腺腺样囊性癌 端粒酶 基因表达 细胞增殖 检测 原位杂交 免疫组化 |
Human telomerase RNA expression in adenoid cystic carcinoma of salivary gland |
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| CHEN Yan,JIANG Hong,YANG Lianjia,et al..Human telomerase RNA expression in adenoid cystic carcinoma of salivary gland[J].Journal of Modern Stomatology,2004,18(2):107-109. | |
| Authors: | CHEN Yan JIANG Hong YANG Lianjia |
| Institution: | CHEN Yan,JIANG Hong,YANG Lianjia,et al. Department of Oral Pathology,Stomatological College,Fourth Military Medical University,Xi'an 710032 |
| Abstract: | Objective To detect the expression of human telomerase RNA(hTR) in adenoid cystic carcinoma(ACC) of salivary glands and to evaluate the relationship between hTR activity and PCNA expression.Methods Nineteen cases of ACC and 4 normal salivary glands were investigated by using in situ-mRNA hybridization(ISH) and immunohistochemical technique.Results Measured by HPIAS-1000 image analysis system,hTR expression was found significantly increased in ACC compared with normal salivary glands(P< 0.001 ). HTR levels were significantly different among ACC phenotypes(P< 0.05 ).The statistic analyses showed that there were some correlations between hTR and PCNA expression.Conclusion hTR may play a crucial role in the tumorigenesis and progress of ACC,it may be an early event in malignancy. |
| Keywords: | Salivary gland Adenoid cystic carcinoma Human telomerase RNA |
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