| 肾静脉套管法建立大鼠腹部心脏移植模型 |
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| 引用本文： | 周云,郭昆亮,杨绍军,杨达宽.肾静脉套管法建立大鼠腹部心脏移植模型[J].实验动物与比较医学,2009,29(2):117-119. |
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| 作者姓名： | 周云 郭昆亮 杨绍军 杨达宽 |
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| 作者单位： | 昆明医学院第二附属医院胸心外科,昆明,650101 |
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| 摘 要： | 目的建立一种快速、有效的大鼠异位心脏移植模型。方法以雄性SD大鼠为供体，Wistar大鼠为受体，将供心的升主动脉与受体的腹主动脉行端侧吻合，切除受体的左肾，将供心的肺动脉与受体的左肾静脉以自制聚乙烯管直接插入法连接。结果35例实验成功32例，成功率91．4％，供心平均缺血时间为（37．8±1．8）。失败原因是吻合口出血，血栓形成。结论本术式操作简单实用，不需手术显微镜，易于推广应用。
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| 关 键 词： | 心脏移植 大鼠 动物模型 |
A Effective Heterotopic Heart Transplantation Model in Rat |
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| ZHOU Yun,GUO Kun-liang,YANG Shao-jun,YANG Da-kuan.A Effective Heterotopic Heart Transplantation Model in Rat[J].Laboratory Animal and Comparative Medicine,2009,29(2):117-119. |
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| Authors: | ZHOU Yun GUO Kun-liang YANG Shao-jun YANG Da-kuan |
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| Institution: | ZHOU Yun, GUO Kun-liang,YANG Shao-jun, YANG Da-kruan (Department of Thoracic and Cardiovascular Surgery, The Second Affiliated Hospital of Kunming Medical College, Kunming 650101, China) |
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| Abstract: | Objective To establish a quick and effective heterotopic heart transplantation model in rat. Method Male SD rats served as donors and Wistar as recipients,the ascending aorta of allograft was anastomosed to the recipient abdominal aorta, the recipient underwent a left nephrectomy, and the right pulmonary artery of allograft inserted into the left renal vein of donors. Results The mean ischemic time was （37.8 ± 1.8） min in 35 experiments. The successful rate was 91.4%. Complications were anastomotic orificces hemorrhange, thrombosis. Conclusion This method has advantage of simpleness, and requiring no operating microscope. So it is easily to be applied. |
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| Keywords: | Heart transplantation Rats Animal models |
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