| 一氧化碳和一氧化氮在新生儿缺氧缺血性脑病发病中的作用 |
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| 引用本文： | 史源,李华强,覃世文,潘捷,潘凤,沈际皋. 一氧化碳和一氧化氮在新生儿缺氧缺血性脑病发病中的作用[J]. 中国实用儿科杂志, 1998, 0(6) |
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| 作者姓名： | 史源 李华强 覃世文 潘捷 潘凤 沈际皋 |
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| 作者单位： | 第三军医大学附属大坪医院 |
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| 摘 要： | 目的：探讨一氧化碳（ＣＯ）和一氧化氮（ＮＯ）在新生儿缺氧缺血性脑病（ＨＩＥ）中的作用。方法：对２８例新生儿ＨＩＥ血浆ＣＯ和ＮＯ水平进行检测，并与３０例正常新生儿对照组比较。结果：与正常对照组比较，２８例新生儿ＨＩＥ患儿血浆ＣＯ、ＮＯ水平显著增高；与轻、中度新生儿ＨＩＥ患儿比较，重度者血浆ＣＯ、ＮＯ水平显著增高；ＣＯ和ＮＯ呈显著正相关。结论：ＣＯ和ＮＯ在新生儿ＨＩＥ的发病过程中具有重要意义。
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| 关 键 词： | 新生儿 一氧化碳 一氧化氮 脑缺氧 脑缺血 |
Role of carbon monoxide and nitric oxide in newborn infants with hypoxic-ischemic encephalopathy |
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| Shi Yuan,Li Huaqiang,Qin Shiwen,et al.. Role of carbon monoxide and nitric oxide in newborn infants with hypoxic-ischemic encephalopathy[J]. Chinese Journal of Practical Pediatrics, 1998, 0(6) |
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| Authors: | Shi Yuan Li Huaqiang Qin Shiwen et al. |
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| Affiliation: | Shi Yuan,Li Huaqiang,Qin Shiwen,et al.Department of Pediatrics,Daping Hospital,Third Military Medical University,Chongqing 400042 |
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| Abstract: | Objective:To investigate the role of carbon monoxide(CO)and nitric oxide(NO)in the pathogenesis of neonatal hypoxic-ischemic encephalopathy(HIE).Methods:Plasma CO and NO levels were studied in 28 newborn infants with HIE,and 30 healthy neonates served as control.Results:The plasma CO and NO levels in 28 newborn infants with HIE were significantly higher than those in the normal controls.The plasma CO and NO levels in the newborn infants with severe HIE were found to be significantly higher than those in the neonates with the light and moderate HIE.Moreover,CO levels were significantly related to NO levels.Conclusion:CO and NO are significant to the pathogenesis of neonatal HIE. |
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| Keywords: | Infant newborn Carbon monoxide Nitric oxide Cerebral ischemia Cerebral anoxia |
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