替硝唑-碘仿-樟脑酚糊剂控制急性根尖周炎的效果评价

目的　比较替硝唑 碘仿 樟脑酚糊剂和甲醛甲酚液用于控制急性根尖周炎的疗效。方法　选择慢性根尖周炎急性发作的恒牙 80颗 ,随机分为 2组 ,替硝唑 碘仿 樟脑酚糊剂组 (T组 )和甲醛甲酚组 (C组 )。记录临床症状和体征 ,拍摄X线片 ,测量根尖阴影面积。常规进行根管预备后 ,T组牙齿根管消毒药物采用替硝唑 碘仿 樟脑酚糊剂 ,C组用甲醛甲酚液纸尖 ,7d复诊根充。初、复诊病例均用标准纸尖法收集根管渗出液 ,计算渗出液体积 ;并用临床根尖周指数 (CPI)进行疗效评定。所得数据用Sigmastat软件进行分析。结果　初诊时T、C组间CPI指数和渗出液体积比较无显著性差异 (P >0 .0 5 ) ,逐步回归分析结果表明 ,根管渗出液体积与叩痛密切相关 (P =0 0 0 3 1) ,X线根尖阴影面积的大小与叩痛、根尖区肿胀程度之间关系密切 (P =0 0 0 4 8和 <0 0 0 0 1) ;两组病例经治疗后的渗出液体积、CPI指数均明显下降 (P <0 .0 0 0 1) ,但组间的渗出液体积、CPI比较差异无显著性 (P >0 .0 5 )。结论　替硝唑、碘仿、樟脑酚糊剂对急性根尖周炎的控制效果与甲醛甲酚液相近

The Clinical Evaluation of Tinidazole-Iodoform-Phenocamphor Paste as an Intra-Canal Sterilization Medication for Acute Periapical Periodontitis

Objective To compare the clinical effect of tinidazole iodoform phenocamphor paste on acute periapical periodontitis with that of formocresol. Methods 80 permanent teeth of acute periapical periodontitis were selected and divided randomly into tinidazole iodoform phenocamphor paste group (T group) and formocresol group (C group). The periapical signs and symptoms were recorded. Radiographs were taken and periapical radiolucent areas were calculated. After root canal preparation, the tinidazole iodoform phenocamphor paste was used as an intra canal dressing medication for 7 days in T group and the formocresol paper point was used in C group. During the course of root canal treatment, the standard paper point sampling method was used to collect and quantify the periapical exudates and the clinical findings were assessed with clinical periapical index (CPI). All statistical analyses were finished with Sigmastat software.Results At the first visit, there was no significant difference between two groups of CPI indexes and exudates volumes ( P >0.05). The stepwise regression results suggested that exudates volumes had a significant correlation to periapical percussion ( P =0.0031). There was a close relationship between radiolucent areas and periapical percussion or swelling degree ( P =0.0048, P <0.0001). After the root canal sterilization, there was a statistically significant decrease in exudates volumes and CPI indexes ( P <0.001), but the difference of exudates volumes and CPI indexes between two groups was not statistically significant ( P >0.05).Conclusion It indicated that tinidazole iodoform phenocamphor paste had the same effect on controlling acute periapical periodontitis as that of formocresol.