| 微量液基稀释法测定化合物特苄康唑的体外抗真菌活性 |
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| 引用本文： | 曹永兵,姜远英,王宁,殷明,张万年. 微量液基稀释法测定化合物特苄康唑的体外抗真菌活性[J]. 中国抗生素杂志, 2000, 25(3): 183-187 |
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| 作者姓名： | 曹永兵 姜远英 王宁 殷明 张万年 |
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| 作者单位： | 第二军医大学药学院,上海,200433 |
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| 基金项目： | 国家自然科学基金!资助项目，批准号 39870 869，军队“九五”医药科研规划重点课题!项目编号 96Z0 30，上海市科技发展基金!资助项目 |
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| 摘 要： | 参照美国国家临床试验标准化委员会提出的标准，以氟康唑，酮康唑和布替萘芬为对照，用微量液基稀释药敏试验方法，测定特苄康唑对１２种临床常见真菌的最低抑菌浓度。结果除烟曲霉外，特苄康唑对其他１１和睦具菌的ＭＩＣ８０均４ｍｇ／Ｌ以下，其体外抗直菌活性明显于氟康唑，尤其对酵母的抗菌活性是氟康唑的８－２５６倍，与酮康唑作用相当。
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| 关 键 词： | 特苄康唑 体外抗真菌活性 最低抑菌浓度 |
In vitro antifungal activity study of terbiaminazole,a new triazole antifungal agent,by broth microdilution testing |
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| Cao Yongbing,Jiang Yuanying,Wang Ning,Yin Ming,Zhang Wannian. In vitro antifungal activity study of terbiaminazole,a new triazole antifungal agent,by broth microdilution testing[J]. Chinese Journal of Antibiotics, 2000, 25(3): 183-187 |
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| Authors: | Cao Yongbing Jiang Yuanying Wang Ning Yin Ming Zhang Wannian |
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| Abstract: | In the broth microdilution testing procedure proposed by the National Committee for Clinical Laboratory Standards (NCCLS), terbiaminazole, a new triazole antifungal agent, with MICs at which 80% of the strains tested are inhibited (MIC 80 s) under 4 mg/L, was more active than fluconazole against different fungi. These results demonstrated that ZJ522 has activity against fungi with broad spectrum and high potency, superior to that of its analogue fluconazole. |
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| Keywords: | Terbiaminazole Antifungal activity Fluconazole Minimal inhibitory concentration |
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