| 基因重组人骨形成蛋白-2与珊瑚/聚乳酸复合异位诱导成骨的实验研究 |
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| 引用本文： | 戴毅敏,陈新梅,毛天球,韩亮,陈富林.基因重组人骨形成蛋白-2与珊瑚/聚乳酸复合异位诱导成骨的实验研究[J].口腔医学研究,2002,18(1):14-15. |
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| 作者姓名： | 戴毅敏 陈新梅 毛天球 韩亮 陈富林 |
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| 作者单位： | 第四军医大学口腔医院,陕西,西安,710032 |
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| 摘 要： | 目的 :观察基因重组人骨形成蛋白 - 2 (rhBMP - 2 )和珊瑚 /聚乳酸形成复合人工骨的异位诱导成骨活性。方法 :把rhBMP - 2和珊瑚 /聚乳酸形成复合人工骨。进行小鼠肌内种植 1、3、6周后 ,组织学观察其异位诱导成骨活性。结果 :rhBMP - 2赋予珊瑚 /聚乳酸骨诱导能力 ,珊瑚 /聚乳酸则充当rhBMP - 2的载体和释放系统 ,对BMP的活性未产生不利影响。与单纯的珊瑚 /聚乳酸相比 ,这种复合人工骨以软骨内成骨的方式诱导成骨。结论 :rhBMP - 2 /珊瑚 /聚乳酸复合人工骨具有良好的生物相容性和骨诱导活性 ,是一种较理想的骨移植替代材料
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| 关 键 词： | 基因重组人骨形成蛋白-2 珊瑚/聚乳酸 复合人工骨 成骨活性 |
| 文章编号： | 1000-4661(2002)01-0014-02 |
| 修稿时间： | 2001年1月8日 |
Experimental Research of Coral/PLA Composite Artificial Bone as Bone Substitute Material and Carrier of rhBMP-2. |
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| DAI Yi-min,CHEN Xin-mei,MAO Tian-qiu,et al..Experimental Research of Coral/PLA Composite Artificial Bone as Bone Substitute Material and Carrier of rhBMP-2.[J].Journal of Oral Science Research,2002,18(1):14-15. |
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| Authors: | DAI Yi-min CHEN Xin-mei MAO Tian-qiu |
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| Institution: | DAI Yi-min,CHEN Xin-mei,MAO Tian-qiu,et al.Stomatological College,Fourth Military Medical University,Xi'an 710032 |
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| Abstract: | e:To study the biodegradable coral/PLA as a new kind of bone substitute material and as carrier of BMP.Methods:The composites were implanted into the muscle pouches of mice after combining with rhBMP-2.After 1,3,6 week, Ectopic osteoinductive activity of rhBMP-2 was examined by histology.Results:Coral/PLA composite could be used as carrier of BMP and could not disturb the osteoinductive activity of BMP.Coral/PLA composite had good biocompatibility.coral/PLA composite may possess definitive osteoinductivety after combining with BPM.Conclusions:rhBMP-2/coral/PLA will be a new bone substitute to be used in repairing bone defect. |
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| Keywords: | rhBMP-2 Coral/PLA Composite artificial bone Osteoconductive |
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