大剂量甲基强的松龙治疗多发性硬化的临床疗效分析(附14例报告)

目的比较大剂量甲基强的松龙和一般剂量糖皮质类固醇治疗多发性硬化的近期疗效。方法大剂量甲基强的松龙（Ⅰ组）治疗14例。甲基强的松龙1．0溶于5％葡萄糖水中静滴3—5d。随后改为强的松50—60mg／d8Am顿服，逐渐减量。一般剂量糖皮质激素（Ⅱ组）治疗17例。地塞米松10—15mg／d溶于5％葡萄糖水中静滴10—14d。逐渐减量。结果Ⅰ组在15d内有12例患者症状缓解。Ⅱ组只有4例缓解。Ⅰ组近期疗效显著优于Ⅱ组（P〈0．01）。结论大剂量甲基强的松龙治疗对急性发作多发性硬化患者症状缓解快且副作用小。因此，对于此类患者首选大剂量甲基强的松龙治疗，以提高近期疗效。

Clinical observation on effect in treatment of multiple sclerosis with high-dose intravenous methylprednisolone pulse therapy

Objective To compare the short-term efficacy of high-close intravenous methylprednisolone with routine-dose glucocorticostcroid in the treatment of multiple sclerosis （MS）. Methods In the first group of high-dose mcthylprednisolone, 14 patients were given methylprednisolone 1000 mg/d intravenously for three to five days followed by prednison 50 - 60mg/d orally, slowly tapering to the lowest maintenance. In the second group of routine-close glucocortieosteroid,17 patients were given dx 10 - 15 intravenously for ten to fourteen clays,followed by gradual dose decreasing. Results The first group was effective for 12 patients whinin 15 days while the second group was effective for 4 patients. As for short-term effect, the first group showed better results than the second group. Conclusion High-dose intravenous methylpredniso]one pulse therapy prevails in short-term effecacy.