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| 中药制剂中非法掺入化学药物成分的测定 | |
| 引用本文： | 刘起中,李慧义,杭太俊. 中药制剂中非法掺入化学药物成分的测定[J]. 中国药师, 2007, 10(8): 735-737 |
| 作者姓名： | 刘起中 李慧义 杭太俊 |
| 作者单位： | 1. 临沂市药品检验所,山东临沂,276001;中国药科大学药物分析室 2. 中国药品生物制品检定所 3. 中国药科大学药物分析室 |
| 摘 要： | 目的:建立检测中药制剂中非法添加化学药物成分氨茶碱、醋酸泼尼松的方法。方法:采用TLC法初筛,HPLC- DAD、LC-MS法确认,对非法掺入的化学药物进行定性鉴别,并以HPLC测定含量。结果:4批中药制剂中分别检测到化学药物成分氨茶碱、醋酸泼尼松。结论:方法选择性强,准确可靠,可作为中药制剂中非法掺入化学药物成分氨茶碱、醋酸泼尼松的有效检验方法。 |
| 关 键 词： | 中药制剂 氨茶碱、醋酸泼尼松 薄层色谱法 高效液相色谱法 液相质谱 |
| 文章编号： | 1008-049X（2007）08-0735-03 |
| 收稿时间： | 2006-11-29 |
| 修稿时间： | 2006-11-292007-06-13 |
Identification of Chemical Compoents Illegally Mixed in Traditional Chinese Medicine Preparations |
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| Liu Qizhong,Li Huiyi,Hang Taijun. Identification of Chemical Compoents Illegally Mixed in Traditional Chinese Medicine Preparations[J]. China Pharmacist, 2007, 10(8): 735-737 | |
| Authors: | Liu Qizhong Li Huiyi Hang Taijun |
| Affiliation: | 1. Shandong Linyi institute for drug control,Shandong, Linyi 276001, China; 2. National Institute for the Control of Pharmaceutical and Biological Products ; 3. Department of Pharmaceutical Analysis, China Pharmaceutical University |
| Abstract: | Objective: To identify aminophylline, prednisone acetate mixed illeglly in traditional Chinese medicine (TCM) preparations. Method: Two Chemical components in TCM preparation were separated, identified and determined by TLC, LC-MS and HPLC. Result:4 batches of products were determined, which contained aminophylline and prednison acetate. Conclusion:The method is specific and sensitive, it can be used to detect the illegal TCM preparations. |
| Keywords: | Traditional Chinese medicine(TCM) preparations Aminophylline Prednisone acetate TLC HPLC-DAD LC-MS |
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