灯盏花素联合血栓通治疗肾病综合征高凝状态的临床观察

[目的]观察灯盏花素和血栓通在原发性肾病综合征中的治疗作用和不良反应,并进行疗效比较。[方法]58例原发性肾病综合征患者,随机分为观察组与对照组,对照组采用激素中、长疗程疗法及对症治疗;观察组在对照组基础上加用灯盏花素及血栓通,疗程均为14天。[结果]治疗组、对照组在治疗前后24h尿蛋白定量、Alb、血脂均有显著变化。但治疗组与对照组比较,治疗组各项指标均明显改善,具有不同程度的减轻血液高凝状态的作用,且无不良反应。[结论]灯盏花素联合血栓通在原发性肾病综合征治疗中疗效确切,不良反应极少,使用安全、方便,值得临床推广应用。

Clinical Observation on Treating Nephrotic Syndrome Hypercoagulable States with Xueshuantong plus Erigeron Injection

[Objective]To investigate the effect of xueshuantong and erigeron injection on anticoagulative therapy in nephrotic syndrome.[Methods]58 patients with primary nephrotic syndrome were randomized in the treatment group who were given xueshuantong and erigeron injection on top of the regular therapy,and the control group was treated only with regular therapy for 14 days.[Results]Lipid lowering and anticoagulative effects were observed in the 2 groups after the therapy.Both groups reduced proteinuria and improved hypoalbuminemia without major adverse events,but the rapeutic effect was better in the treatment group than that in the control group.[Conclusion]Both xueshuantong and erigeron injection are suggested to be safe and effective for anticoagulation in primary nephrotic syndrome.