|
|||||
|
|
| 脑出血大鼠脑内NGF和BDNF蛋白表达变化的研究 | |
| 引用本文： | 石秋艳,何俊芳,孙惠芳,孙鹏,刘斌,张国志,王长友,燕霞.脑出血大鼠脑内NGF和BDNF蛋白表达变化的研究[J].中国医药指南,2010,8(7):8-10. |
| 作者姓名： | 石秋艳 何俊芳 孙惠芳 孙鹏 刘斌 张国志 王长友 燕霞 |
| 作者单位： | 1. 华北煤炭医学院附属医院,063000 2. 唐山市铁路中心医院,063000 3. 河北工程大学附属医院,056002 |
| 摘 要： | 目的观察脑出血大鼠脑组织内神经生长因子(NGF)和脑源性神经营养因子(BDNF)表达的变化,探讨神经营养因子在脑出血后脑损伤的作用。方法SD雄性大鼠随机分为正常组、假手术组和脑出血组,通过自体血脑内注射法建立脑出血动物模型,采用免疫组织化学法检测脑出血后3、6、12、24、48、72h、7d脑组织中NGF和BDNF蛋白表达情况。结果脑出血组6hNGF表达增加,12hBDNF表达增加,均于24h达高峰,与假手术组及正常组相比差异具有显著性(P<0.05)。结论脑出血后可诱导NGF和BDNF蛋白表达增加,有利于对脑出血后损伤神经元的保护和修复。 |
| 关 键 词： | 脑出血 脑源性神经营养因子 神经生长因子 |
The Expressions of NGF and BDNF in the Rats with Intracerebral Hemorrhage |
|
| SHI Qiu-yan,HE Jun-fang,SUN Hui-fang,SUN Peng,LIU Bin,ZHANG Guo-zhi,WANG Chang-you,YAN Xia.The Expressions of NGF and BDNF in the Rats with Intracerebral Hemorrhage[J].Guide of China Medicine,2010,8(7):8-10. | |
| Authors: | SHI Qiu-yan HE Jun-fang SUN Hui-fang SUN Peng LIU Bin ZHANG Guo-zhi WANG Chang-you YAN Xia |
| Institution: | SHI Qiu-yan1,HE Jun-fang1,SUN Hui-fang1,SUN Peng2,LIU Bin1,ZHANG Guo-zhi1,WANG Chang-you1,YAN Xia3(1 Department of Neurology,Affiliated Hospital of North China Coal Medical College,Tangshan 063000,China,2 Tangshan Tielu Central Hospital,3 The Affi liated Hospital of Hebei University of Engineering,H,an 056002,China) |
| Abstract: | Objective To observe the expression on distribution of NGF and BDNF in rat brain with intracerebral hemorrhage,in order to explore the fuction of the neurotrophic factors against intracerebral hemorrhage injury. Methods Adult male Sprague-Dawle rats were randomly seperated into three groups:normal group,sham operation group,intracerebral hemorrhage group,then the model of intracerebral hemorrhage(ICH) was established in rats by intracerebral injection with autogenous blood. The protein expression of BDNF an... |
| Keywords: | Intracerebral hemorrhage Brain-derivedneurotropic factor Nerve growth factor |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |